The members of the genus Alphavirus are positive-sense RNA viruses, which are
predominantly transmitted to vertebrates by a mosquito vector. Alphavirus disease in …

Abstract Positive-sense RNA ((+) RNA) viruses such as hepatitis C virus exploit host cells by
subverting host proteins, remodelling subcellular membranes, co-opting and modulating …

A key to tackling the coronavirus disease 2019 (COVID-19) pandemic is to understand how
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) manages to outsmart host …

Cells have evolved highly specialized sentinels that detect viral infection and elicit an
antiviral response. Among these, the stress-sensing protein kinase R, which is activated by …

Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus responsible for
major outbreaks of disease since 2004 in the Indian Ocean islands, South east Asia, and the …

The positive-strand RNA viruses initiate their amplification in the cell from a single genome
delivered by virion. This single RNA molecule needs to become involved in replication …

While biomolecular condensates have emerged as an important biological phenomenon,
mechanisms regulating their composition and the ways that viruses hijack these …

RNA granules are structures within cells that impart key regulatory measures on gene
expression. Two general types of RNA granules are conserved from yeast to mammals …

Alphaviruses are plus-strand RNA viruses that cause encephalitis, rash, and arthritis. The
nonstructural protein (nsP) precursor polyprotein is translated from genomic RNA and …

Traditionally, vaccine development involves tradeoffs between immunogenicity and safety.
Live-attenuated vaccines typically offer rapid and durable immunity but have reduced safety …