Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer's trial selection and disease monitoring

NJ Ashton, S Janelidze, N Mattsson-Carlgren… - Nature medicine, 2022 - nature.com
Blood biomarkers indicative of Alzheimer's disease (AD) pathology are altered in both
preclinical and symptomatic stages of the disease. Distinctive biomarkers may be optimal for …

Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer's disease

M Milà-Alomà, NJ Ashton, M Shekari, G Salvadó… - Nature Medicine, 2022 - nature.com
Blood biomarkers indicating elevated amyloid-β (Aβ) pathology in preclinical Alzheimer's
disease are needed to facilitate the initial screening process of participants in disease …

MicroRNAs as potential biomarkers in temporal lobe epilepsy and mesial temporal lobe epilepsy

B Martinez, PV Peplow - Neural Regeneration Research, 2023 - journals.lww.com
Temporal lobe epilepsy is the most common form of focal epilepsy in adults, accounting for
one third of all diagnosed epileptic patients, with seizures originating from or involving …

An examination of a novel multipanel of CSF biomarkers in the Alzheimer's disease clinical and pathological continuum

C Van Hulle, EM Jonaitis, TJ Betthauser… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction This study examines the utility of a multipanel of cerebrospinal fluid (CSF)
biomarkers complementing Alzheimer's disease (AD) biomarkers in a clinical research …

Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age

TJ Betthauser, RL Koscik, EM Jonaitis, SL Allison… - Brain, 2020 - academic.oup.com
This study investigated differences in retrospective cognitive trajectories between amyloid
and tau PET biomarker stratified groups in initially cognitively unimpaired participants …

Association of age at menopause and hormone therapy use with tau and β-amyloid positron emission tomography

GT Coughlan, TJ Betthauser, R Boyle… - JAMA …, 2023 - jamanetwork.com
Importance Postmenopausal females represent around 70% of all individuals with
Alzheimer disease. Previous literature shows elevated levels of tau in cognitively …

Neuropsychiatric and cognitive symptoms across the Alzheimer disease clinical spectrum: cross-sectional and longitudinal associations

WS Eikelboom, E van den Berg, EH Singleton… - Neurology, 2021 - AAN Enterprises
Background and Objectives To investigate the prevalence and trajectories of
neuropsychiatric symptoms (NPS) in relation to cognitive functioning in a cohort of β-amyloid …

Association of neighborhood context, cognitive decline, and cortical change in an unimpaired cohort

JFV Hunt, NM Vogt, EM Jonaitis, WR Buckingham… - Neurology, 2021 - AAN Enterprises
Objective To test the hypothesis that neighborhood-level disadvantage is associated with
longitudinal measures of neurodegeneration and cognitive decline in an unimpaired cohort …

[HTML][HTML] Effect of a 2-year diet intervention with walnuts on cognitive decline. The Walnuts And Healthy Aging (WAHA) study: a randomized controlled trial

A Sala-Vila, C Valls-Pedret, S Rajaram… - The American journal of …, 2020 - Elsevier
Background Walnut consumption counteracts oxidative stress and inflammation, 2 drivers of
cognitive decline. Clinical data concerning effects on cognition are lacking. Objectives The …

Aerobic exercise training and neurocognitive function in cognitively normal older adults: a one‐year randomized controlled trial

T Tarumi, NR Patel, T Tomoto, E Pasha… - Journal of internal …, 2022 - Wiley Online Library
Background Current evidence is inconsistent on the benefits of aerobic exercise training for
preventing or attenuating age‐related cognitive decline in older adults. Objective To …