The DISC locus is located at the breakpoint of a balanced t (1; 11) chromosomal
translocation in a large and unique Scottish family. This translocation segregates in a highly …

The thalamus is a crucial node for brain physiology and part of functional and structural
pathways relevant for schizophrenia. Relatively few imaging studies on schizophrenia have …

Objective: The authors used a custom array of 1,536 single-nucleotide polymorphisms
(SNPs) to interrogate 94 functionally relevant candidate genes for schizophrenia and identify …

Mutations in FOXP2, a member of the forkhead family of transcription factor genes, are the
only known cause of developmental speech and language disorders in humans. To date …

Disrupted-In-Schizophrenia-1 (DISC1) is a promising susceptibility gene for major mental
illness, but the mechanism of the clinical association is unknown. We searched for DISC1 …

Studies in adolescents and adults have demonstrated that polymorphisms in putative
psychiatric risk genes are associated with differences in brain structure, but cannot address …

Disrupted-in-schizophrenia 1 (DISC1) is a genetic susceptibility factor for schizophrenia and
related severe psychiatric conditions. DISC1 is a multifunctional scaffold protein that is able …

Schizophrenia has a complex genetic underpinning and variations in a number of candidate
genes have been identified that confer risk of developing the disorder. We report in the …

Several polymorphisms in the Disrupted-in-Schizophrenia-1 (DISC1) gene are reported to
be associated with schizophrenia. However, to date, there has been little effort to evaluate …

The causes of schizophrenia remain elusive. In a large Scottish pedigree, a balanced
translocation t (1; 11)(q42. 1; q14. 3) disrupting the DISC1 and DISC2 genes segregates …