Neoadjuvant and adjuvant therapies have made significant progress in cancer treatment.
However, tumor adjuvant therapy still faces challenges due to the intrinsic heterogeneity of …

Simple Summary Mitochondria, often called “the powerhouse of the cell”, generate most of
the energy required for all cellular processes. Mitochondria also provide a platform for …

Human caseinolytic protease P (ClpP) is required for the regulatory hydrolysis of
mitochondrial proteins. Allosteric ClpP agonists dysfunctionally activate mitochondrial ClpP …

For diverse human tumors, growth and metastasis are dependent on proline synthesis, but
the mechanisms underlying this association are not clear. Proline incorporated into collagen …

Glycolytic metabolism generates energy and intermediates for biomass production. Tumor-
associated glycolysis is upregulated compared to normal tissues in response to tumor cell …

ClpP activators ONC201 and related small molecules (TR compounds, Madera
Therapeutics), have demonstrated significant anti-cancer potential in vitro and in vivo …

Introduction ClpP is a highly conserved serine protease that plays a crucial role in
maintaining protein homeostasis in both bacterial cells and human mitochondria. Several …

Breast cancer cells exhibit metabolic heterogeneity based on tumour aggressiveness.
Glycolysis and mitochondrial respiration are two major metabolic pathways for ATP …

Transcription of the mitochondrial genome is essential for the maintenance of oxidative
phosphorylation (OXPHOS) and other functions directly related to this unique genome …

The mTOR inhibitor, everolimus, is an important clinical management component of
metastatic ER+ breast cancer (BC). However, most patients develop resistance and …