Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems
The deaminase-like fold includes, in addition to nucleic acid/nucleotide deaminases, several
catalytic domains such as the JAB domain, and others involved in nucleotide and ADP …
catalytic domains such as the JAB domain, and others involved in nucleotide and ADP …
Minimal functional sites allow a classification of zinc sites in proteins
C Andreini, I Bertini, G Cavallaro - PLoS One, 2011 - journals.plos.org
Zinc is indispensable to all forms of life as it is an essential component of many different
proteins involved in a wide range of biological processes. Not differently from other metals …
proteins involved in a wide range of biological processes. Not differently from other metals …
Diversification of AID/APOBEC-like deaminases in metazoa: multiplicity of clades and widespread roles in immunity
AID/APOBEC deaminases (AADs) convert cytidine to uridine in single-stranded nucleic
acids. They are involved in numerous mutagenic processes, including those underpinning …
acids. They are involved in numerous mutagenic processes, including those underpinning …
An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations
When bacterial cells come in contact, antagonism mediated by the delivery of toxins
frequently ensues. The potential for such encounters to have long-term beneficial …
frequently ensues. The potential for such encounters to have long-term beneficial …
1.92 Angstrom zinc-free APOBEC3F catalytic domain crystal structure
The APOBEC3 family of DNA cytosine deaminases is capable of restricting the replication of
HIV-1 and other pathogens. Here, we report a 1.92 Å resolution crystal structure of the Vif …
HIV-1 and other pathogens. Here, we report a 1.92 Å resolution crystal structure of the Vif …
APOBEC2 is a monomer in solution: implications for APOBEC3G models
Although the physiological role of APOBEC2 is still largely unknown, a crystal structure of a
truncated variant of this protein was determined several years ago [Prochnow, C.(2007) …
truncated variant of this protein was determined several years ago [Prochnow, C.(2007) …
Streptomyces lividans blasticidin S deaminase and its application in engineering a blasticidin S-producing strain for ease of genetic manipulation
L Li, J Wu, Z Deng, TM Zabriskie… - Applied and environmental …, 2013 - Am Soc Microbiol
Blasticidin S is a peptidyl nucleoside antibiotic produced by Streptomyces
griseochromogenes that exhibits strong fungicidal activity. To circumvent an effective DNA …
griseochromogenes that exhibits strong fungicidal activity. To circumvent an effective DNA …
Catalytic zinc site and mechanism of the metalloenzyme PR-AMP cyclohydrolase
The enzyme N 1-(5′-phosphoribosyl) adenosine-5′-monophosphate cyclohydrolase (PR-
AMP cyclohydrolase) is a Zn2+ metalloprotein encoded by the hisI gene. It catalyzes the …
AMP cyclohydrolase) is a Zn2+ metalloprotein encoded by the hisI gene. It catalyzes the …
O2‐independent demethylation of trimethylamine N‐oxide by Tdm of Methylocella silvestris
Bacterial trimethylamine N‐oxide (TMAO) demethylase, Tdm, carries out an unusual oxygen‐
independent demethylation reaction, resulting in the formation of dimethylamine and …
independent demethylation reaction, resulting in the formation of dimethylamine and …
Complex structure of Bacillus subtilis RibG: the reduction mechanism during riboflavin biosynthesis
SC Chen, YH Lin, HC Yu, SH Liaw - Journal of Biological Chemistry, 2009 - ASBMB
Bacterial RibG is a potent target for antimicrobial agents, because it catalyzes consecutive
deamination and reduction steps in the riboflavin biosynthesis. In the N-terminal deaminase …
deamination and reduction steps in the riboflavin biosynthesis. In the N-terminal deaminase …