Ghrelin plays an important physiological role in modulating GH secretion, insulin secretion
and glucose metabolism. Ghrelin has direct effects on pancreatic islet function. Also, ghrelin …

Ghrelin and its receptor, the growth hormone secretagogue receptor 1a (GHSR1a), are
implicated in the regulation of glucose metabolism via direct actions in the pancreatic islet …

Aims/hypothesis Proinflammatory and proapoptotic cytokines such as TNF-α are
upregulated in human obesity. We evaluated the association between ghrelin isoforms …

Insulin secretion from pancreatic islet β‐cells is stimulated by glucose. Glucose‐induced
insulin release is potentiated or suppressed by hormones and neural substances. Ghrelin …

Since its discovery, many physiologic functions have been ascribed to ghrelin, a gut derived
hormone. The presence of a median fatty acid side chain on the ghrelin peptide is required …

OBJECTIVE Ghrelin reportedly restricts insulin release in islet β-cells via the Gαi2 subtype of
G-proteins and thereby regulates glucose homeostasis. This study explored whether ghrelin …

Given its wide spectrum of biological activities such as growth hormone (GH) release,
feeding stimulation, adiposity and cardiovascular actions, the discovery of ghrelin opened …

Background: Infusion of ghrelin to supraphysiologic levels inhibits glucose-stimulated insulin
secretion, reduces insulin sensitivity, and worsens glucose tolerance in humans. Objective …

Objectives: Administration of ghrelin inhibits the acute insulin response to glucose and
worsens IV glucose tolerance in healthy subjects. Evidence from preclinical studies …

Background: Ghrelin, a peptide mainly produced by stomach XA cells. It plays a pivotal role
in the regulation of food intake and energy metabolism, including glucose metabolism and …