Cancer microenvironment is critical for tumorigenesis and cancer progression. The
extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells …

Alteration in the density and composition of extracellular matrix (ECM) occurs in tumors. The
alterations toward both stiffness and degradation are contributed to tumor growth and …

Carcinoma-associated fibroblasts (CAF) are key players in the tumor microenvironment.
Here, we characterize four CAF subsets in breast cancer with distinct properties and levels …

Metastasis causes most cancer-related deaths; however, the efficacy of anti-metastatic drugs
is limited by incomplete understanding of the biological mechanisms that drive metastasis …

Numerous cancers express platelet-derived growth factors (PDGFs) and PDGF receptors
(PDGFRs). By directly stimulating tumour cells in an autocrine manner or by stimulating …

This review summarizes the roles of CAFs in forming a “cancerized” fibrotic stroma favorable
to tumor initiation and dissemination, in particular highlighting the functions of the …

Pancreatic ductal adenocarcinoma (PDAC) is almost universally fatal, in large part due to a
protective fibrotic barrier generated by tumor-associated stromal (TAS) cells. This barrier is …

Glycosaminoglycans (GAGs) and proteoglycans (PGs) are essential components of the
extracellular matrix (ECM) with pivotal roles in cellular mechanosensing pathways. GAGs …

The biophysical and biomechanical properties of the extracellular matrix (ECM) are crucial
in the processes of cell differentiation and proliferation. However, it is unclear to what extent …

Abstract Type 2 DCs (DC2s) comprise the majority of conventional DCs within most tumors;
however, little is known about their ability to initiate and sustain antitumor immunity, as most …