Biocatalysis has revolutionized chemical synthesis, providing sustainable methods for
preparing various organic molecules. In enzyme-mediated organic synthesis, most reactions …

Biocatalysis is a highly valued enabling technology for pharmaceutical research and
development as it can unlock synthetic routes to complex chiral motifs with unparalleled …

Flavoprotein monooxygenases (FPMOs) are single-or two-component enzymes that
catalyze a diverse set of chemo-, regio-and enantioselective oxyfunctionalization reactions …

The development of mild, efficient, and enantioselective methods for preparing chiral
fluorinated compounds has been a long‐standing challenge. Herein, we report a …

Plastic waste management is a pressing ecological, social, and economic challenge. The
saliva of the lepidopteran Galleria mellonella larvae is capable of oxidizing and …

Plastic contamination currently threatens a wide variety of ecosystems and presents
damaging repercussions and negative consequences for many wildlife species. Sustainable …

This review analyzes a development in biochemistry, enzymology and biotechnology that
originally came as a surprise. Following the establishment of directed evolution of …

C–N bond formation is integral to modern chemical synthesis due to the ubiquity of nitrogen
heterocycles in small-molecule pharmaceuticals and agrochemicals. Alkene hydroamination …

We report enantioselective one-carbon ring expansion of aziridines to make azetidines as a
new-to-nature activity of engineered “carbene transferase” enzymes. A laboratory-evolved …

Among the molecular mechanisms of adaptation in biology, enzyme functional
diversification is indispensable. By allowing organisms to expand their catalytic repertoires …