Extracellular nucleotides (eg, ATP, ADP, UTP, UDP) released by inflammatory cells interact
with specific purinergic P2 type receptors to modulate their recruitment and activation. The …

Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …

The initial reports regarding a cytotoxic role of calcium ions were published over 30 years
ago. In neurons, calcium ions can gain entry into the cell through several mechanisms …

Temporal lobe epilepsy (TLE) is one of the most common types of epilepsy, yet
approximately one-third of patients are refractory to current anticonvulsive drugs, which …

Connexins are chordate gap junction channel proteins that, by enabling direct
communication between the cytosols of adjacent cells, create a unique cell signalling …

Connexin 43 (Cx43) gap junctions and hemichannels mediate astrocyte intercellular
communication in the central nervous system under normal conditions and contribute to …

Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

Intercellular calcium (Ca2+) waves (ICWs) represent the propagation of increases in
intracellular Ca2+ through a syncytium of cells and appear to be a fundamental mechanism …

Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide; it is characterized by dopaminergic neurodegeneration in the substantia nigra …