Sexual dimorphism in colon cancer
M Abancens, V Bustos, H Harvey, J McBryan… - Frontiers in …, 2020 - frontiersin.org
A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …
Young women (18–44 years) with CRC have a better survival outcome compared to men of …
ATM mutations in cancer: therapeutic implications
Activation of checkpoint arrest and homologous DNA repair are necessary for maintenance
of genomic integrity during DNA replication. Germ-line mutations of the ataxia telangiectasia …
of genomic integrity during DNA replication. Germ-line mutations of the ataxia telangiectasia …
Biomarkers for homologous recombination deficiency in cancer
Defective DNA repair is a common hallmark of cancer. Homologous recombination is a DNA
repair pathway of clinical interest due to the sensitivity of homologous recombination …
repair pathway of clinical interest due to the sensitivity of homologous recombination …
The role of the core non-homologous end joining factors in carcinogenesis and cancer
BJ Sishc, AJ Davis - Cancers, 2017 - mdpi.com
DNA double-strand breaks (DSBs) are deleterious DNA lesions that if left unrepaired or are
misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis …
misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis …
Enhancing the landscape of colorectal cancer using targeted deep sequencing
Targeted next-generation sequencing (NGS) technology detects specific mutations that can
provide treatment opportunities for colorectal cancer (CRC) patients. We included 145 CRC …
provide treatment opportunities for colorectal cancer (CRC) patients. We included 145 CRC …
ATM has a major role in the double-strand break repair pathway dysregulation in sporadic breast carcinomas and is an independent prognostic marker at both mRNA …
S Rondeau, S Vacher, L De Koning, A Briaux… - British journal of …, 2015 - nature.com
Background: Ataxia telangiectasia mutated (ATM) is a kinase that has a central role in the
maintenance of genomic integrity by activating cell cycle checkpoints and promoting repair …
maintenance of genomic integrity by activating cell cycle checkpoints and promoting repair …
Identification and monitoring of mutations in circulating cell-free tumor DNA in hepatocellular carcinoma treated with lenvatinib
Y Fujii, A Ono, CN Hayes, H Aikata… - Journal of Experimental …, 2021 - Springer
Background There has been a recent surge in interest in predicting biological effects
associated with genomic alterations in order to implement personalized cancer treatment …
associated with genomic alterations in order to implement personalized cancer treatment …
The Ku complex: recent advances and emerging roles outside of non-homologous end-joining
S Abbasi, G Parmar, RD Kelly, N Balasuriya… - Cellular and Molecular …, 2021 - Springer
Since its discovery in 1981, the Ku complex has been extensively studied under multiple
cellular contexts, with most work focusing on Ku in terms of its essential role in non …
cellular contexts, with most work focusing on Ku in terms of its essential role in non …
Prognostic impact of ATM mutations in patients with metastatic colorectal cancer
Tumors bearing homologous recombination deficiency are extremely sensitive to DNA
double strand breaks induced by several chemotherapeutic agents. ATM gene, encoding a …
double strand breaks induced by several chemotherapeutic agents. ATM gene, encoding a …
Comprehensive analysis of prognostic and genetic signatures for general transcription factor III (GTF3) in clinical colorectal cancer patients using bioinformatics …
Colorectal cancer (CRC) has the fourth-highest incidence of all cancer types, and its
incidence has steadily increased in the last decade. The general transcription factor III …
incidence has steadily increased in the last decade. The general transcription factor III …