Succinimides are well recognized heterocyclic compounds in drug discovery which produce
diverse therapeutically related applications in pharmacological practices. Researches in …

Epilepsy is a common disease of the nervous system characterized by transient brain
dysfunction caused by an abnormal electrical discharge from the brain neurons. The …

In recent years, chiral molecules (especially enantiomers) have occupied a significant place
in pharmaceutical industry and have played a prominent role in the development of new …

Diabetic neuropathic pain (DNP) is a common, complex, and severe complication of
diabetes. It can lead to increased mortality, lower-limb amputations, and distressing …

(R)-7 [(R)-AS-1] showed broad-spectrum antiseizure activity across in vivo mouse seizure
models: maximal electroshock (MES), 6 Hz (32/44 mA), acute pentylenetetrazol (PTZ), and …

Recently, compound KA-11 was identified as a promising candidate for a new broad-
spectrum anticonvulsant. This compound revealed wide protective activity across the most …

Introduction Despite the availability of around 30 antiseizure medications, 1/3 of patients
with epilepsy fail to become seizure-free upon pharmacological treatment. Available …

We developed a focused set of original hybrid pyrrolidine-2, 5-dione derivatives with potent
anticonvulsant and antinociceptive properties. These hybrid compounds demonstrated …

The present study aimed to design and synthesize a new series of hybrid compounds with
pyrrolidine-2, 5-dione and thiophene rings in the structure as potential anticonvulsant and …

We report herein a series of water-soluble analogues of previously described
anticonvulsants and their detailed in vivo and in vitro characterization. The majority of these …