Atherosclerotic plaques impair vascular function and can lead to arterial obstruction and
tissue ischaemia. Rupture of an atherosclerotic plaque within a coronary artery can result in …

Lipid-enriched diets are often used to induce or accelerate the rate of atherosclerotic lesion
development in murine models of atherosclerosis. It appears that the induction of persistent …

Nonalcoholic fatty liver disease (NAFLD) is usually characterized with disrupted bile acid
(BA) homeostasis. However, the exact role of certain BA in NAFLD is poorly understood …

We explored the influence of the hydrophilic-hydrophobic balance of a series of natural bile
acids on cholesterol absorption in the mouse. Male C57L/J mice were fed standard chow or …

Sepsis, a critical condition resulting from the systemic inflammatory response to a severe
microbial infection, represents a global public health challenge. However, effective treatment …

Background Mice deficient in the LDL receptor (Ldlr−/− mice) have been widely used as a
model to mimic human atherosclerosis. However, the time-course of atherosclerotic lesion …

Obstructive sleep apnea (OSA), characterized by intermittent hypoxia and hypercapnia
(IHC), affects the composition of the gut microbiome and metabolome. The gut microbiome …

Bile acid signaling is a critical regulator of glucose and energy metabolism, mainly through
the nuclear receptor FXR and the G protein-coupled receptor TGR. The purpose of the …

Objective—A semisynthetic diet with varying amounts of cholesterol was used to achieve
hypercholesterolemia and atherosclerosis in LDL receptor–deficient (LDLR−/−) mice …

Myrcludex B acts as a hepatitis B and D virus entry inhibitor blocking the sodium
taurocholate cotransporting polypeptide (SLC10A1). We investigated the effects of …