Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …

Neuroinflammation, a protective response of the central nervous system (CNS), is
associated with the pathogenesis of neurodegenerative diseases. The CNS is composed of …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide,
characterized by progressive neuron degeneration or loss due to excessive accumulation of …

Alzheimer's Disease (AD) contributes to most cases of dementia. Its prominent
neuropathological features are the extracellular neuritic plaques and intercellular …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
by cognitive decline and the presence of two core pathologies, amyloid β plaques and …

Abstract Interleukin-6 (IL-6) is a pleiotropic pro-inflammatory cytokine. Its deregulation is
associated with chronic inflammation, and multifactorial auto-immune disorders. It mediates …

Alzheimer's disease (AD) is associated with memory impairment and altered peripheral
metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery …

Apolipoprotein E (APOE) is a strong genetic risk factor for late-onset Alzheimer's disease
(LOAD). APOE4 increases and APOE2 decreases risk relative to APOE3. In the P301S …

Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …