Both COPD and lung cancer are major worldwide health concerns owing to cigarette
smoking, and represent a huge, worldwide, preventable disease burden. Whilst the majority …

Muscle dysfunction often occurs in patients with chronic obstructive pulmonary disease
(COPD) and may involve both respiratory and locomotor (peripheral) muscles. The loss of …

Key points• The discovery of microRNAs (miRNAs) has established new mechanisms that
control health, but little is known about the regulation of skeletal muscle miRNAs in response …

In the next decade, Chronic Obstructive Pulmonary Disease (COPD) will be a major leading
cause of death worldwide. Impaired muscle function and mass are common systemic …

MicroRNAs (miRNAs) are small non-coding RNAs which can act as master regulators of
gene expression, modulate almost all biological process and are essential for maintaining …

Abstract Sirtuin-1 (SIRT1) and SIRT6, NAD+-dependent Class III protein deacetylases, are
putative anti-aging enzymes, down-regulated in patients with chronic obstructive pulmonary …

Majority of the human genome is transcribed into RNAs with absent or limited protein-coding
potential. microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are two major families …

The skeletal muscles play an essential role in life, providing the mechanical basis for
respiration and movement. Skeletal muscle dysfunction is prevalent in all stages of chronic …

Cachexia and muscle wasting are well recognized as common and partly reversible features
of chronic obstructive pulmonary disease (COPD), adversely affecting disease progression …

The advent of techniques such as microarrays and high-throughput sequencing has
revolutionized our ability to examine messenger RNA (mRNA) expression within the …