Influence of sex on the progression of chronic kidney disease
J Neugarten, L Golestaneh - Mayo Clinic Proceedings, 2019 - Elsevier
The role that sex plays in the development and progression of chronic kidney disease
remains a subject of controversy. The lack of clarity in this important area reflects complex …
remains a subject of controversy. The lack of clarity in this important area reflects complex …
The aging heart
YA Chiao, PS Rabinovitch - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Aging results in progressive deteriorations in the structure and function of the heart and is a
dominant risk factor for cardiovascular diseases, the leading cause of death in Western …
dominant risk factor for cardiovascular diseases, the leading cause of death in Western …
Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging
Background—Age is a major risk for cardiovascular diseases. Although mitochondrial
reactive oxygen species have been proposed as one of the causes of aging, their role in …
reactive oxygen species have been proposed as one of the causes of aging, their role in …
Postmenopausal hypertension: mechanisms and therapy
Hypertension in women is often undiagnosed or inade-quately treated, especially after
menopause when cardiovascular risk increases. In premenopausal women, endogenous …
menopause when cardiovascular risk increases. In premenopausal women, endogenous …
The aging heart: a molecular and clinical challenge
Aging is associated with an increasing burden of morbidity, especially for cardiovascular
diseases (CVDs). General cardiovascular risk factors, ischemic heart diseases, heart failure …
diseases (CVDs). General cardiovascular risk factors, ischemic heart diseases, heart failure …
Glomerulosclerosis and tubulointerstitial fibrosis are attenuated with 17β-estradiol in the aging Dahl salt sensitive rat
C Maric, K Sandberg… - Journal of the American …, 2004 - journals.lww.com
This study examined the effects of estrogen deficiency by ovariectomy (OVX) and 17β-
estradiol (E 2) replacement (OVX+ E 2) on glomerulosclerosis and tubulointerstitial fibrosis …
estradiol (E 2) replacement (OVX+ E 2) on glomerulosclerosis and tubulointerstitial fibrosis …
[HTML][HTML] PPARα agonist fenofibrate improves diabetic nephropathy in db/db mice
Peroxisome proliferator-activated receptor α (PPARα) is a member of the ligand-activated
nuclear receptor superfamily, and plays an important role in lipid metabolism and glucose …
nuclear receptor superfamily, and plays an important role in lipid metabolism and glucose …
Podocyte aging: why and how getting old matters
The effects of healthy aging on the kidney, and how these effects intersect with
superimposed diseases, are highly relevant in the context of the population's increasing …
superimposed diseases, are highly relevant in the context of the population's increasing …
[HTML][HTML] Induction of diabetes in aged C57B6 mice results in severe nephropathy: an association with oxidative stress, endoplasmic reticulum stress, and inflammation
J Wu, R Zhang, M Torreggiani, A Ting, H Xiong… - The American journal of …, 2010 - Elsevier
Kidney aging is a slowly progressive process that is postulated to be accelerated by
intervening diseases, such as diabetes, due in part to the addition of excessive stress and …
intervening diseases, such as diabetes, due in part to the addition of excessive stress and …
The genetic background significantly impacts the severity of kidney cystic disease in the Pkd1RC/RC mouse model of autosomal dominant polycystic kidney disease
J Arroyo, D Escobar-Zarate, HH Wells, MM Constans… - Kidney international, 2021 - Elsevier
Autosomal dominant polycystic kidney disease (ADPKD), primarily due to PKD1 or PKD2
mutations, causes progressive kidney cyst development and kidney failure. There is …
mutations, causes progressive kidney cyst development and kidney failure. There is …