The development of single-cell and spatial transcriptomics methods was instrumental in the
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …

Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and
regeneration of most tissues. They can differentiate along multiple connective lineages, but …

The success of regenerative medicine in various clinical applications depends on the
appropriate selection of the source of mesenchymal stem cells (MSCs). Indeed, the source …

Bone marrow mesenchymal lineage cells are a heterogeneous cell population involved in
bone homeostasis and diseases such as osteoporosis. While it is long postulated that they …

Senescence drives organismal aging, yet the deep characterization of senescent cells in
vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully …

Bone marrow stromal cells (BMSCs) are versatile mesenchymal cell populations
underpinning the major functions of the skeleton, a majority of which adjoin sinusoidal blood …

Bone is maintained by coupled activities of bone-forming osteoblasts/osteocytes and bone-
resorbing osteoclasts. Alterations in this relationship can lead to pathologic bone loss such …

Cellular senescence is a persistently hypoproliferative state with diverse stressors in a
specific aging microenvironment. Senescent cells have a double‐edged sword effect: they …

Bone marrow mesenchymal stromal cells (BMSCs), identified as pericytes comprising the
hematopoietic niche, are a group of heterogeneous cells composed of multipotent stem …

Adipose tissue depots in distinct anatomical locations mediate key aspects of metabolism,
including energy storage, nutrient release, and thermogenesis. Although adipocytes make …