Disruptions to dopamine and noradrenergic neurotransmission are noted in several neurodegenerative and psychiatric disorders. Neuromelanin-sensitive (NM)-MRI offers a …
Objective Parkinson's disease (PD) is a common neurological disorder with variable clinical manifestations and magnetic resonance imaging (MRI) findings. We propose a handcrafted …
Protein aggregation, mitochondrial dysfunction, iron dyshomeostasis, increased oxidative damage and inflammation are pathognomonic features of Parkinson's disease (PD) and …
G Palermo, S Giannoni, G Bellini, G Siciliano… - International Journal of …, 2021 - mdpi.com
A major goal of current clinical research in Parkinson's disease (PD) is the validation and standardization of biomarkers enabling early diagnosis, predicting outcomes, understanding …
L Chen, Y Wang, J Huang, B Hu, W Huang - Frontiers in Genetics, 2022 - frontiersin.org
Background: Parkinson's disease (PD) is a common, age-related, and progressive neurodegenerative disease. Growing evidence indicates that immune dysfunction plays an …
Segmenting deep brain structures from magnetic resonance images is important for patient diagnosis, surgical planning, and research. Most current state‐of‐the‐art solutions follow a …
Objectives The study aimed to develop a deep neural network (DNN)–based noise reduction and image quality improvement by only using routine clinical scans and evaluate …
EW Wang, GL Brown, MM Lewis, LC Jellen… - Movement …, 2023 - Wiley Online Library
Background Susceptibility magnetic resonance imaging (MRI) is sensitive to iron‐related changes in the substantia nigra pars compacta (SNc), the key pathologic locus of …
P Tiwari, S Tiwari - Advances in Colloid and Interface Science, 2023 - Elsevier
Neurodegenerative disorders (NDDs) are caused by progressive loss of functional neurons following the aggregation and fibrillation of proteins in the central nervous system. The …