The spread of microbial antibiotic resistance has seriously threatened public health globally.
Non-antibiotic stressors have significantly contributed to the evolution of bacterial antibiotic …

For tuberculosis to be eradicated, the transmission of Multi-Drug-Resistant and eXtensively
Drug Resistant strains of Mycobacterium tuberculosis (MDR and XDR-TB) must be …

Using cryo-electron microscopy (cryo-EM), we determined the structure of the Escherichia
coli 70S ribosome with a global resolution of 2.0 Å. The maps reveal unambiguous …

Whole-genome sequencing (WGS) is used increasingly in public-health laboratories for
typing and characterizing foodborne pathogens. To evaluate the performance of existing …

Antibiotic resistance is one of the most challenging issues in public health. Antibiotics have
been increasingly used not only for humans and animals but also for crop protection as …

Methylation of nucleotides in rRNA is one of the basic mechanisms of bacterial resistance to
protein synthesis inhibitors. The genes for corresponding methyltransferases have been …

RNA modifications are involved in numerous biological processes and are present in all
RNA classes. These modifications can be constitutive or modulated in response to adaptive …

Informed antibiotic prescription offers a practical solution to antibiotic resistance problem.
With the increasing affordability of different sequencing technologies, molecular-based …

Translational fidelity refers to accuracy during protein synthesis and is maintained in all
three domains of life. Translational errors occur at base levels during normal conditions and …

To explore how co-occurring non-antibiotic environmental stressors affect evolutionary
trajectories toward antibiotic resistance, we exposed susceptible Escherichia coli K-12 …