Objective: To review the biochemistry and biological activities of leukotrienes, focusing on
their role in the mediation of inflammatory diseases. Data Sources: MEDLINE (1966-1994) …

In some patients with asthma, aspirin (ASA) and all nonsteroidal anti-inflammatory drugs that
inhibit cyclooxygenase enzymes (cyclooxygenase-1 and-2) precipitate asthmatic attacks …

The methodology for EPOS2012 has been the same as for the other two productions.
Leaders in the field were invited to critically appraise the literature and write a report on a …

This best-selling resource has a worldwide reputation as the leader in its field. Focusing on
human immunology and biology, while also reporting on scientific experimentation and …

Aspirin causes bronchoconstriction in aspirin-intolerant asthma (AIA) patients by triggering
cysteinyl-leukotriene (cys-LT) production, probably by removing PGE2-dependent inhibition …

Background Patients with asthma who have aspirin sensitivity have greater cysteinyl
leukotriene production and greater airway hyperresponsiveness to the effects of inhaled …

Exogenous prostaglandin E2 (PGE2) given by inhalation almost completely abrogates
aspirin-induced asthma and the accompanying increase in cysteinyl-leukotrienes …

5‐Lipoxygenase (5‐LO) and its activating protein (FLAP) are both required for cellular
leukotriene (LT) synthesis, with 5‐LO catalyzing both the synthesis of (5S)‐5‐hydroperoxy 6 …

The mechanism of aspirin (acetylsalicylic acid [ASA]) sensitivity associated with severe
asthma and chronic rhinosinusitis with nasal polyps (“aspirin triad”) has been attributed to …

The pathogenesis of aspirin-induced asthma (AIA) has not yet been clearly elucidated,
although eicosanoid metabolites appear to play an important role. We hypothesized that …