IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses
M Clement, JL Forbester, M Marsden… - Nature …, 2022 - nature.com
Interferon-induced transmembrane protein 3 (IFITM3) is a restriction factor that limits viral
pathogenesis and exerts poorly understood immunoregulatory functions. Here, using human …
pathogenesis and exerts poorly understood immunoregulatory functions. Here, using human …
Single-cell RNA-Seq analysis reveals cell subsets and gene signatures associated with rheumatoid arthritis disease activity
M Binvignat, BY Miao, C Wibrand, MM Yang… - JCI …, 2024 - pmc.ncbi.nlm.nih.gov
Rheumatoid arthritis (RA) management leans toward achieving remission or low disease
activity. In this study, we conducted single-cell RNA sequencing (scRNA-Seq) of peripheral …
activity. In this study, we conducted single-cell RNA sequencing (scRNA-Seq) of peripheral …
Recognition of Immune Cell Markers of COVID‐19 Severity with Machine Learning Methods
L Chen, Z Mei, W Guo, SJ Ding… - BioMed Research …, 2022 - Wiley Online Library
COVID‐19 is hypothesized to be linked to the host's excessive inflammatory immunological
response to SARS‐CoV‐2 infection, which is regarded to be a major factor in disease …
response to SARS‐CoV‐2 infection, which is regarded to be a major factor in disease …
Weighted Gene Co-expression Network Analysis and Machine Learning Validation for Identifying Major Genes Related to Sjogren's Syndrome
Q Luo, K Wu, H Li, H Wang, C Wang, D Xia - Biochemical Genetics, 2024 - Springer
Sjogren's syndrome (SS) is an autoimmune disorder characterized by dry mouth and dry
eyes. Its pathogenic mechanism is currently unclear. This study aims to integrate weighted …
eyes. Its pathogenic mechanism is currently unclear. This study aims to integrate weighted …
Deciphering Cell-types and Gene Signatures Associated with Disease Activity in Rheumatoid Arthritis using Single Cell RNA-sequencing
M Binvignat, BY Miao, C Wibrand, MM Yang… - bioRxiv, 2023 - biorxiv.org
Objective Single cell profiling of synovial tissue has previously identified gene signatures
associated with rheumatoid arthritis (RA) pathophysiology, but synovial tissue is difficult to …
associated with rheumatoid arthritis (RA) pathophysiology, but synovial tissue is difficult to …
IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses
M Clement, JL Forbester, M Marsden, P Sabberwal… - Biorxiv, 2021 - biorxiv.org
Interferon induced transmembrane protein 3 (IFITM3) is an important viral restriction factor in
viral pathogenesis that also exhibits poorly understood immune regulatory functions. Here …
viral pathogenesis that also exhibits poorly understood immune regulatory functions. Here …
Host immunity against acute viral respiratory infection: investigation of IFITM3 & discovery of SARS-CoV-2-specific T cell responses
Z Yin - 2022 - ora.ox.ac.uk
Appropriate host immune responses to acute viral respiratory infections are necessary for
viral clearance and can determine clinical disease severity. Two such respiratory infections …
viral clearance and can determine clinical disease severity. Two such respiratory infections …