Biotherapies in uveitis

M Leclercq, AC Desbois, F Domont, G Maalouf… - Journal of clinical …, 2020 - mdpi.com
Non-infectious uveitis (NIU) represents one of the leading causes of blindness in developed
countries. The therapeutic strategy aims to rapidly control intra-ocular inflammation, prevent …

Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non‐infectious uveitis

LB Ferreira, KA Williams, G Best… - Clinical & …, 2023 - Wiley Online Library
Characterised by intraocular inflammation, non‐infectious uveitis includes a large group of
autoimmune and autoinflammatory diseases that either involve the eye alone or have both …

Anti–tumor necrosis factor α versus tocilizumab in the treatment of refractory uveitic macular edema: a multicenter study from the French Uveitis Network

M Leclercq, A Andrillon, G Maalouf, P Sève, P Bielefeld… - Ophthalmology, 2022 - Elsevier
Purpose To analyze the factors associated with response (control of ocular inflammation and
corticosteroid-sparing effect) to biologics (anti–tumor necrosis factor [TNF]-α agents and …

Comparison of the treatment results for Behçet uveitis in patients treated with infliximab and interferon

N Yalçindag, HC Köse - Ocular immunology and inflammation, 2020 - Taylor & Francis
Purpose: To compare the efficacy and safety of infliximab and interferon in patients with
refractory Behçet uveitis. Methods: Medical records of 20 patients treated with infliximab …

The current status of biological treatment for uveitis

C Gaggiano, J Sota, S Gentileschi… - Expert Review of …, 2020 - Taylor & Francis
Introduction Noninfectious uveitis represents one of the leading causes of blindness in
developed Countries, compromising patients' quality of life and social functioning. The main …

[HTML][HTML] Effectiveness of SB5, an adalimumab biosimilar, in patients with noninfectious uveitis: a real-life monocentric experience

J Sota, S Gentileschi, A Vitale, C Gaggiano… - Asia-Pacific Journal of …, 2021 - Elsevier
Purpose: Several concerns have arisen with biosimilars in terms of immunogenicity, safety
issues, loss of efficacy, and extrapolation to other indications. The study aim was to evaluate …

Long-term outcomes of treatment with biological agents in eyes with refractory, active, noninfectious intermediate uveitis, posterior uveitis, or panuveitis

A Al-Janabi, A El Nokrashy, L Sharief, V Nagendran… - Ophthalmology, 2020 - Elsevier
Purpose To examine a large cohort of patients treated with biologic agents for active
noninfectious intermediate uveitis, posterior uveitis, or panuveitis (NIPPU) and to compare …

Perspectives for immunotherapy in noninfectious immune mediated uveitis

S Touhami, J Gueudry, M Leclercq… - Expert Review of …, 2021 - Taylor & Francis
Introduction: Noninfectious uveitis (NIU) is one of the leading causes of blindness
worldwide. In adult patients, anterior NIU is usually managed with topical corticosteroids. In …

Outcomes of uveitic macular edema in the first-line antimetabolites as steroid-sparing treatment uveitis trial

E Tsui, SR Rathinam, JA Gonzales, R Thundikandy… - Ophthalmology, 2022 - Elsevier
Purpose To evaluate the outcomes of uveitic macular edema at 6 and 12 months in patients
treated with methotrexate or mycophenolate mofetil. Design Subanalysis of a block …

Local versus systemic therapy for Noninfectious Uveitis (NIU)

EL Chang, L Sobrin - Seminars in Ophthalmology, 2023 - Taylor & Francis
The mainstay of treatment for noninfectious uveitis (NIU) is immunosuppressant therapy.
This may come in a localized form that is administered specifically to the eye or a systemic …