Halogenation activity of mammalian heme peroxidases

J Arnhold, E Malle - Antioxidants, 2022 - mdpi.com
Mammalian heme peroxidases are fascinating due to their unique peculiarity of oxidizing
(pseudo) halides under physiologically relevant conditions. These proteins are able either to …

Reinforcing rigor and reproducibility expectations for use of sex and gender in cardiovascular research

ML Lindsey, AJ LeBlanc… - American Journal …, 2021 - journals.physiology.org
In 1993, the National Institutes of Health (NIH) enacted the Revitalization Act to establish
guidelines for inclusion of women and minorities in clinical research. In 2016, the NIH …

Hemodynamic assessment of diastolic function for experimental models

LM Ogilvie, BA Edgett, JS Huber… - American Journal …, 2020 - journals.physiology.org
Traditionally, the evaluation of cardiac function has focused on systolic function; however,
there is a growing appreciation for the contribution of diastolic function to overall cardiac …

Halogen-induced chemical injury to the mammalian cardiopulmonary systems

DR Addis, S Aggarwal, A Lazrak, T Jilling… - …, 2021 - journals.physiology.org
The halogens chlorine (Cl2) and bromine (Br2) are highly reactive oxidizing elements with
widespread industrial applications and a history of development and use as chemical …

[HTML][HTML] Phosgene inhalation causes hemolysis and acute lung injury

S Aggarwal, T Jilling, S Doran, I Ahmad, JE Eagen… - Toxicology letters, 2019 - Elsevier
Abstract Phosgene (Carbonyl Chloride, COCl 2) remains an important chemical
intermediate in many industrial processes such as combustion of chlorinated hydrocarbons …

Calpain in the cleavage of alpha-synuclein and the pathogenesis of Parkinson's disease

R Shams, NL Banik, A Haque - Progress in molecular biology and …, 2019 - Elsevier
Parkinson's disease (PD) devastates 6.3 million people, ranking it as one of the most
prevalent neurodegenerative motor disorders worldwide. PD patients may manifest …

Echocardiographic, biochemical, and electrocardiographic correlates associated with progressive pulmonary arterial hypertension

A Zaky, I Zafar, JX Masjoan-Juncos… - Frontiers in …, 2021 - frontiersin.org
Background: Pulmonary arterial hypertension (PAH) is a progressive proliferative
vasculopathy associated with mechanical and electrical changes, culminating in increased …

Epigenetic mechanisms of alveolar macrophage activation in chemical-induced acute lung injury

S Ahmad, W Nasser, A Ahmad - Frontiers in Immunology, 2024 - frontiersin.org
Airways, alveoli and the pulmonary tissues are the most vulnerable to the external
environment including occasional deliberate or accidental exposure to highly toxic chemical …

Vascular Endothelial Growth Factor‐121 Administration Mitigates Halogen Inhalation‐Induced Pulmonary Injury and Fetal Growth Restriction in Pregnant Mice

DR Addis, JA Lambert, C Ren, S Doran… - Journal of the …, 2020 - Am Heart Assoc
Background Circulating levels of sFLT‐1 (soluble fms‐like tyrosine kinase 1), the
extracellular domain of vascular endothelial growth factor (VEGF) receptor 1, and its ratio to …

Hyaluronan and halogen‐induced airway hyperresponsiveness and lung injury

A Lazrak, W Song, T Zhou, S Aggarwal… - Annals of the New …, 2020 - Wiley Online Library
Abstract Chlorine (Cl2) and bromine (Br2) are produced in large quantities throughout the
world and used in the industry and the sanitation of water. These halogens can pose a …