The sirtuin family in health and disease

QJ Wu, TN Zhang, HH Chen, XF Yu, JL Lv… - … and Targeted Therapy, 2022 - nature.com
Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Clinical application of intermittent fasting for weight loss: progress and future directions

KA Varady, S Cienfuegos, M Ezpeleta… - Nature Reviews …, 2022 - nature.com
Intermittent fasting diets have become very popular in the past few years, as they can
produce clinically significant weight loss. These diets can be defined, in the simplest of …

Intermittent fasting and metabolic health

I Vasim, CN Majeed, MD DeBoer - Nutrients, 2022 - mdpi.com
Given the ongoing strain that the obesity epidemic has placed on public health outcomes,
new and effective approaches to weight control are needed. One approach to improving …

Cardiometabolic benefits of intermittent fasting

KA Varady, S Cienfuegos, M Ezpeleta… - Annual review of …, 2021 - annualreviews.org
This review aims to summarize the effects of intermittent fasting on markers of
cardiometabolic health in humans. All forms of fasting reviewed here—alternate-day fasting …

[HTML][HTML] Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes

EF Sutton, R Beyl, KS Early, WT Cefalu, E Ravussin… - Cell metabolism, 2018 - cell.com
Intermittent fasting (IF) improves cardiometabolic health; however, it is unknown whether
these effects are due solely to weight loss. We conducted the first supervised controlled …

Flipping the metabolic switch: understanding and applying the health benefits of fasting

SD Anton, K Moehl, WT Donahoo, K Marosi, SA Lee… - …, 2018 - Wiley Online Library
Objective Intermittent fasting (IF) is a term used to describe a variety of eating patterns in
which no or few calories are consumed for time periods that can range from 12 hours to …

Impact of intermittent fasting on health and disease processes

MP Mattson, VD Longo, M Harvie - Ageing research reviews, 2017 - Elsevier
Humans in modern societies typically consume food at least three times daily, while
laboratory animals are fed ad libitum. Overconsumption of food with such eating patterns …

Metabolic effects of intermittent fasting

RE Patterson, DD Sears - Annual review of nutrition, 2017 - annualreviews.org
The objective of this review is to provide an overview of intermittent fasting regimens,
summarize the evidence on the health benefits of intermittent fasting, and discuss …

Intermittent fasting: is the wait worth the weight?

MC Stockman, D Thomas, J Burke, CM Apovian - Current obesity reports, 2018 - Springer
Abstract Purpose of Review We review the underlying mechanisms and potential benefits of
intermittent fasting (IF) from animal models and recent clinical trials. Recent Findings …

Calorie restriction and aging in humans

EW Flanagan, J Most, JT Mey… - Annual review of …, 2020 - annualreviews.org
Calorie restriction (CR), the reduction of dietary intake below energy requirements while
maintaining optimal nutrition, is the only known nutritional intervention with the potential to …