Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning

ME Bouton, S Maren, GP McNally - Physiological reviews, 2021 - journals.physiology.org
This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …

Dorsal striatal circuits for habits, compulsions and addictions

DM Lipton, BJ Gonzales, A Citri - Frontiers in systems neuroscience, 2019 - frontiersin.org
Here, we review the neural circuit bases of habits, compulsions, and addictions, behaviors
which are all characterized by relatively automatic action performance. We discuss relevant …

Still a “hidden island”? The rodent insular cortex in drug seeking, reward, and risk

MS McGregor, RT LaLumiere - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Abstract MCGREGOR, MS, and RT LaLumiere. Still a “hidden island”? The rodent insular
cortex in drug seeking, reward, and risk. NEUROSCI BIOBEHAV REV 21 (1) XXX-XXX …

The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands

JG Howland, R Ito, CC Lapish, FR Villaruel - … & Biobehavioral Reviews, 2022 - Elsevier
Emerging evidence implicates rodent medial prefrontal cortex (mPFC) in tasks requiring
adaptation of behavior to changing information from external and internal sources. However …

[HTML][HTML] Infralimbic cortex functioning across motivated behaviors: Can the differences be reconciled?

KE Nett, RT LaLumiere - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
The rodent infralimbic cortex (IL) is implicated in higher order executive functions such as
reward seeking and flexible decision making. However, the precise nature of its role in these …

[HTML][HTML] Increased cocaine motivation is associated with degraded spatial and temporal representations in IL-NAc neurons

CM Cameron, M Murugan, JY Choi, EA Engel… - Neuron, 2019 - cell.com
Craving for cocaine progressively increases in cocaine users during drug-free periods,
contributing to relapse. The projection from the infralimbic cortex to the nucleus accumbens …

Differential effects of dorsal and ventral medial prefrontal cortex inactivation during natural reward seeking, extinction, and cue-induced reinstatement

JP Caballero, GB Scarpa, L Remage-Healey… - Eneuro, 2019 - eneuro.org
Rodent dorsal medial prefrontal cortex (mPFC), typically prelimbic cortex, is often described
as promoting actions such as reward seeking, whereas ventral mPFC, typically infralimbic …

Persistent increase of accumbens cocaine ensemble excitability induced by IRK downregulation after withdrawal mediates the incubation of cocaine craving

G He, Z Huai, C Jiang, B Huang, Z Tian, Q Le… - Molecular …, 2023 - nature.com
The incubation phenomenon, cue-induced drug craving progressively increasing over
prolonged withdrawal, accounts for persistent relapse, leading to a dilemma in the treatment …

Infralimbic projections to the nucleus accumbens shell and amygdala regulate the encoding of cocaine extinction learning

KE Nett, AR Zimbelman, MS McGregor… - Journal of …, 2023 - Soc Neuroscience
Prior evidence indicates that the infralimbic cortex (IL) mediates the ongoing inhibition of
cocaine seeking following self-administration and extinction training in rats, specifically …

Activation of infralimbic to nucleus accumbens shell pathway suppresses conditioned aversion in male but not female rats

SW Hurley, RM Carelli - Journal of Neuroscience, 2020 - Soc Neuroscience
Hedonic processing plays an integral role in directing appropriate behavior, but disrupted
hedonic processing is associated with psychiatric disorders such as depression. The …