The outer retina is nourished from the choroid, a capillary bed just inside the sclera. O2,
glucose, and other nutrients diffuse out of the choroid and then filter through a monolayer of …

Microglia are the resident immune cells of the central nervous system (CNS), including the
retina. Similar to brain microglia, retinal microglia are responsible for retinal surveillance …

Abstract Analysis of retina cell type-specific epigenetic and transcriptomic signatures is
crucial to understanding the pathophysiology of retinal degenerations such as age-related …

Background Aging is associated with functional decline of neurons and increased incidence
of both neurodegenerative and ocular disease. Photoreceptor neurons in Drosophila …

Age-related macular degeneration (AMD) is a major cause of blindness that affects people
over 60. While aging is the prominent factor in AMD, studies have reported a higher …

How many RBPMS+ retinal ganglion cells (RGCs) does a standard C57BL/6 laboratory
mouse have on average and is this number substrain-or sex-dependent? Do RGCs of …

Importance The mechanisms behind the phenotypic variability and reduced penetrance in
autosomal recessive Stargardt disease (STGD1), often a blinding disease, are poorly …

Gene expression alterations occurring with aging have been described for a multitude of
species, organs, and cell types. However, most of the underlying studies rely on static …

Abstract EFEMP1 R345W is a dominant mutation causing Doyne honeycomb retinal
dystrophy/malattia leventinese (DHRD/ML), a rare blinding disease with clinical pathology …

The systemic delivery of tamoxifen (Tam) to activate inducible CreERT2-loxP transgenic
mouse systems is now widely used in neuroscience studies. This critical technological …