Influenza A virus (IAV) contains a genome with eight single-stranded, negative-sense RNA
segments that encode 17 proteins. During its assembly, all eight separate viral RNA (vRNA) …

Influenza A viruses (IAV) are responsible for recurrent influenza epidemics and occasional
devastating pandemics in humans and animals. They belong to the Orthomyxoviridae family …

The influenza A virus (IAV) is a continuous health threat to humans as well as animals due to
its recurring epidemics and pandemics. The IAV genome is segmented and the eight …

The non-structural protein 1 (NS1) of influenza A viruses plays important roles in viral fitness
and in the process of interspecies adaptation. It is one of the most polymorphic and mutation …

The H1N1 influenza virus responsible for the most recent pandemic in 2009 (H1N1pdm) has
spread to swine populations worldwide while it replaced the previous seasonal H1N1 virus …

RNA secondary structures play a key role in splicing, gene expression, microRNA
biogenesis, RNA editing, and other biological processes. The importance of RNA structures …

The fitness effects of synonymous mutations can provide insights into biological and
evolutionary mechanisms. We analyzed the experimental fitness effects of all single …

Recombinant viral vectors represent one of the most promising platforms for creating a new
generation of vaccines against tuberculosis. We constructed a vaccine candidate based on …

Influenza A virus (IAV) NS1 protein is one of the key viral factors responsible for virus-host
interactions. NS1 counteracts host antiviral defense, participates in the processing and …

RNA secondary structures in RNA viral genomes play important roles in a range of functions,
including packaging, protection from cellular nucleases, and regulating viral replication …