[HTML][HTML] Organotypic brain slice cultures: A review

C Humpel - Neuroscience, 2015 - Elsevier
In vitro cell cultures are an important tool for obtaining insights into cellular processes in an
isolated system and a supplement to in vivo animal experiments. While primary dissociated …

The blood–brain barrier as a target in traumatic brain injury treatment

SC Thal, W Neuhaus - Archives of medical research, 2014 - Elsevier
Traumatic brain injury (TBI) is one of the most frequent causes of death in the young
population. Several clinical trials have unsuccessfully focused on direct neuroprotective …

[HTML][HTML] Nrf2 regulates ROS production by mitochondria and NADPH oxidase

S Kovac, PR Angelova, KM Holmström, Y Zhang… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Background Nuclear factor (erythroid-derived 2) factor 2 (Nrf2) is a crucial transcription factor
mediating protection against oxidants. Nrf2 is negatively regulated by cytoplasmic Kelch-like …

Extracellular adenosine promotes cell migration/invasion of Glioblastoma Stem-like Cells through A3 Adenosine Receptor activation under hypoxia

Á Torres, JI Erices, F Sanchez, P Ehrenfeld, L Turchi… - Cancer letters, 2019 - Elsevier
Glioblastoma (GBM) is the brain tumor with the worst prognosis composed of a cell
subpopulation called Glioblastoma Stem-like Cells (GSCs) responsible for tumor recurrence …

Small molecule phosphorescent probes for O 2 imaging in 3D tissue models

RI Dmitriev, AV Kondrashina, K Koren, I Klimant… - Biomaterials …, 2014 - pubs.rsc.org
Monitoring of oxygenation is important for physiological experiments investigating the
growth, differentiation and function of individual cells in 3D tissue models. Phosphorescence …

Effects of Phenolic-Rich Pinus densiflora Extract on Learning, Memory, and Hippocampal Long-Term Potentiation in Scopolamine-Induced Amnesic Rats

KJ Kim, ES Hwang, MJ Kim, CS Rha, MC Song… - Antioxidants, 2022 - mdpi.com
Alzheimer's disease is the most common type of dementia with cognitive impairment.
Various plant-derived phenolics are known to alleviate cognitive impairment in Alzheimer's …

The malleable brain: plasticity of neural circuits and behavior–a review from students to students

N Schaefer, C Rotermund, EM Blumrich… - Journal of …, 2017 - Wiley Online Library
One of the most intriguing features of the brain is its ability to be malleable, allowing it to
adapt continually to changes in the environment. Specific neuronal activity patterns drive …

Organotypic cultures of cerebellar slices as a model to investigate demyelinating disorders

F Doussau, JL Dupont, D Neel… - Expert Opinion on …, 2017 - Taylor & Francis
Introduction: Demyelinating disorders, characterized by a chronic or episodic destruction of
the myelin sheath, are a leading cause of neurological disability in young adults in western …

Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin

C Garcia-Diaz, A Pöysti, E Mereu, MP Clements… - Cell Reports, 2023 - cell.com
Glioblastoma (GBM) recurrence originates from invasive margin cells that escape surgical
debulking, but to what extent these cells resemble their bulk counterparts remains unclear …

Ferrostatin-1 polarizes microglial cells toward M2 phenotype to alleviate inflammation after intracerebral hemorrhage

L Huang, Y Zhang, L Zhao, Q Chen, L Li - Neurocritical care, 2022 - Springer
Background Intracerebral hemorrhage (ICH) is one of the most lethal stroke types and lacks
effective therapeutic regimens. Recently, evidence has suggested the involvement of the …