Depression is one of the leading causes of disability, and, if left unmanaged, it can increase
the risk for suicide. The evidence base on the determinants of depression is fragmented …

Background Virtual reality (VR) is being used more and more often as a therapeutic tool in
psychology or psychiatry. In recent years, VR interventions appear more extensively also in …

Importance Major depressive disorder (MDD), a common mental disorder in the US, may
have substantial impact on the lives of affected individuals. If left untreated, MDD can …

Observational studies suggested a bidirectional correlation between depression and
metabolic syndrome (MetS) and its components. However, the causal associations between …

Background Depression is frequently accompanied by other mental disorders and various
somatic diseases; however, previous comorbidity studies often relied on self-reported data …

Importance Depression is a common mental health disorder in the US. Depressive
symptoms have been associated with increased cardiovascular disease incidence and …

Responses to highly aversive or potentially traumatic events are typically defined in terms of
binary outcomes, most commonly the presence or absence of post-traumatic stress disorder …

Synchronizing circadian (24 h) rhythms in physiology and behavior with the environmental
light-dark cycle is critical for maintaining optimal health. Dysregulation of the circadian …

Ketamine is an open channel blocker of ionotropic glutamatergic N-Methyl-D-Aspartate
(NMDA) receptors. The discovery of its rapid antidepressant effects in patients with …

Background Understanding patterns of multimorbidity in the US older adult population and
their relationship with mortality is important for reducing healthcare utilization and improving …