Protein–protein interactions: switch from classical methods to proteomics and bioinformatics-based approaches

AG Ngounou Wetie, I Sokolowska, AG Woods… - Cellular and molecular …, 2014 - Springer
Following the sequencing of the human genome and many other organisms, research on
protein-coding genes and their functions (functional genomics) has intensified …

Investigation of stable and transient protein–protein interactions: past, present, and future

AG Ngounou Wetie, I Sokolowska, AG Woods… - …, 2013 - Wiley Online Library
This article presents an overview of the literature and a review of recent advances in the
analysis of stable and transient protein–protein interactions (PPI s) with a focus on their …

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

PD Patel, P Yan, PM Seidler, HJ Patel, W Sun… - Nature chemical …, 2013 - nature.com
Although the Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α,
Hsp90β, Grp94 and Trap-1, has important roles in malignancy, the contribution of each …

Regulation of hepatitis B virus infection by Rab5, Rab7, and the endolysosomal compartment

A Macovei, C Petrareanu, C Lazar, P Florian… - Journal of …, 2013 - Am Soc Microbiol
Despite important progress toward deciphering human hepatitis B virus (HBV) entry into host
cells, many aspects of the early steps of the life cycle remained completely obscure …

Mass spectrometry-based proteomics of human milk to identify differentially expressed proteins in women with breast cancer versus controls

R Aslebagh, D Whitham, D Channaveerappa… - Proteomes, 2022 - mdpi.com
It is thought that accurate risk assessment and early diagnosis of breast cancer (BC) can
help reduce cancer-related mortality. Proteomics analysis of breast milk may provide …

[HTML][HTML] Investigation of the effects of downregulation of jumping translocation breakpoint (JTB) protein expression in MCF7 cells for potential use as a biomarker in …

M Jayathirtha, AN Neagu, D Whitham… - American journal of …, 2022 - ncbi.nlm.nih.gov
MCF7 is a commonly used luminal type A non-invasive/poor-invasive human breast cancer
cell line that does not usually migrate or invade compared with MDA-MB-231 highly …

[HTML][HTML] Investigation of the effects of overexpression of jumping translocation breakpoint (JTB) protein in MCF7 cells for potential use as a biomarker in breast cancer

M Jayathirtha, AN Neagu, D Whitham… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Jumping translocation breakpoint (JTB) gene acts as a tumor suppressor or an oncogene in
different malignancies, including breast cancer (BC), where it was reported as …

Identification of posttranslational modifications (PTMs) of proteins by mass spectrometry

R Aslebagh, KL Wormwood… - Advancements of mass …, 2019 - Springer
There are only 30,000 human genes, which, according to the central dogma from biology, it
means that there should be 30,000 mRNA and 30,000 proteins. However, there are at least …

Single-cell RNA sequencing reveals the lineage of malignant epithelial cells and upregulation of TAGLN2 promotes peritoneal metastasis in gastric cancer

C Ji, J Zhao, H Chen, Z Wang, T Cai, C Tian… - Clinical and …, 2023 - Springer
Background Peritoneal metastasis (PM) is an important factor contributing to poor prognosis
in patients with gastric cancer (GC). Transcriptomic sequencing has been used to explore …

Investigating the Function of Human Jumping Translocation Breakpoint Protein (hJTB) and Its Interacting Partners through In-Solution Proteomics of MCF7 Cells

M Jayathirtha, D Whitham, S Alwine, M Donnelly… - Molecules, 2022 - mdpi.com
Human jumping translocation breakpoint (hJTB) gene is located on chromosome 1q21 and
is involved in unbalanced translocation in many types of cancer. JTB protein is ubiquitously …