Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …

Application of silyl functionalities is one of the most promising strategies among various
'elements chemistry'approaches for the development of novel and distinctive drug …

This review aims to highlight the role of silicon in drug discovery. Silicon and carbon are
often regarded as being similar with silicon located directly beneath carbon in the same …

Bioisosterism is one of the leading strategies in medicinal chemistry for the design and
modification of drugs, consisting in replacing an atom or a substituent with a different atom or …

Simmons–Smith cyclopropanation is a widely used reaction in organic synthesis for
stereospecific conversion of alkenes into cyclopropane. The utility of this reaction can be …

d-Arabinofuranosyl-pyrimidine and-purine nucleoside analogues containing alkylthio-,
acetylthio-or 1-thiosugar substituents at the C2'position were prepared from the …

The Simmons–Smith–Furukawa reaction was used to generate 4′/5′-
spirocyclopropanated uridine analogs from electron-rich exocyclic enol esters. During …

A highly efficient rhodium-catalyzed asymmetric hydrosilylation of aldehydes, ketones, and
α, β-unsaturated ketones with dihydrosilanes is developed, that allows the rapid assembly of …

The biologically active compound 3-aminopropylsilatrane (a compound with a
pentacoordinated silicon atom) underwent an aza-Michael reaction with various acrylates …

C–Si bonds were constructed by utilizing copper hydride-catalyzed asymmetric
hydrosilylation of 1, 2-dihydroquinolines, affording various chiral 4-silyl-1, 2, 3, 4 …