RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …

The translational challenges in the field of precision oncology are in part related to the
biological complexity and diversity of this disease. Technological advances in genomics …

The cell ecology and spatial niche implicated in the dynamic and sequential process of lung
adenocarcinoma (LUAD) from adenocarcinoma in situ (AIS) to minimally invasive …

Summary We analyzed 2,532 lung adenocarcinomas (LUAD) to identify the
clinicopathological and genomic features associated with metastasis, metastatic burden …

Simple Summary Immune escape mechanisms have been identified in every step of lung
tumorigenesis. A heterogeneous ensemble of immune evasion processes shapes the …

Metabolic reprogramming evolves during cancer initiation and progression. However,
thorough understanding of metabolic evolution from preneoplasia to lung adenocarcinoma …

APOBEC3 enzymes are cytosine deaminases implicated in cancer. Precisely when
APOBEC3 expression is induced during cancer development remains to be defined. Here …

Background Along with the popularity of low-dose computed tomography lung cancer
screening, an increasing number of lung ground-glass opacity (GGO) lesions are detected …

Background Immune checkpoint blockade (ICB) has been improving patient outcomes of
non-small cell lung cancer (NSCLC), but its effectiveness is highly subjective to individual …

T cell-mediated immune therapies have emerged as a promising treatment modality in
different malignancies including colorectal cancer (CRC). However, only a fraction of …