The major facilitator superfamily (MFS) is the largest known superfamily of secondary active
transporters. MFS transporters are responsible for transporting a broad spectrum of …

The serum level of iron in humans is tightly controlled by the action of the hormone hepcidin
on the iron efflux transporter ferroportin. Hepcidin regulates iron absorption and recycling by …

Iron overload disorders represent an important class of human diseases. Of the primary iron
overload conditions, by far the most common and best studied is HFE-related …

Hemochromatosis (HC) is a genetically heterogeneous disorder in which uncontrolled
intestinal iron absorption may lead to progressive iron overload (IO) responsible for …

Ferroportin is an iron exporter essential for releasing cellular iron into circulation. Ferroportin
is inhibited by a peptide hormone, hepcidin. In humans, mutations in ferroportin lead to …

Iron is an essential transition metal for its involvement in several crucial biological functions,
the most notable being oxygen storage and transport. Due to its high reactivity and potential …

Iron is unique among all minerals in that humans have no regulatable excretory pathway to
eliminate excess iron after it is absorbed. Iron deficiency anemia occurs when absorbed iron …

Due to its pivotal role in orchestrating vital cellular functions and metabolic processes, iron is
an essential component of the human body and a main micronutrient in the human diet …

The role of iron in the formation and functioning of erythrocytes, and to a lesser degree of
white blood cells, is well established, but the relationship between iron and platelets is less …

Ferroportin (Fpn) is a transporter that releases ferrous ion (Fe 2+) from cells and is important
for homeostasis of iron in circulation. Export of one Fe 2+ by Fpn is coupled to import of two …