Evasion of antitumour immunity is a hallmark of cancer. STING, a putative innate immune
signalling adaptor, has a pivotal role in mounting antitumour immunity by coordinating …

Ex vivo systems that incorporate features of the tumor microenvironment and model the
dynamic response to immune checkpoint blockade (ICB) may facilitate efforts in precision …

While primarily studied for their roles in innate immune response, the IκB kinase (IKK)-
related kinases TANK-binding kinase 1 (TBK1) and IKKε also promote the oncogenic …

STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown
mechanisms. Here, we found that these mutants induce chronic activation of ER stress and …

Background: Programmed death-ligand 1 (PD-L1) may be induced by oncogenic signals or
can be upregulated via interferon gamma (IFN-γ). We have explored whether the expression …

Upon sensing cytosolic DNA, the enzyme cGAS induces innate immune responses that
underpin anti-microbial defenses and certain autoimmune diseases. Missense mutations of …

The pathogenesis of autoimmune diseases, such as rheumatoid arthritis (RA) and systemic
lupus erythematosus (SLE) is driven by genetic predisposition and environmental triggers …

Summary Herpes simplex virus 1 (HSV-1) establishes infections in humans and mice, but
some non-human primates exhibit resistance via unknown mechanisms. Innate immune …

The gut microbiota has been evolving with its host along the time creating a symbiotic
relationship. In this study, we assess the role of the host genome in the modulation of the …

Mapping the proteomic landscape of mitochondria with spatiotemporal precision plays a
pivotal role in elucidating the delicate biological functions and complex relationship with …