Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

JM Keaton, Z Kamali, T Xie, A Vaez, A Williams… - Nature …, 2024 - nature.com
Hypertension affects more than one billion people worldwide. Here we identify 113 novel
loci, reporting a total of 2,103 independent genetic signals (P< 5× 10− 8) from the largest …

Association Study of IGF-1 rs35767 and rs6214 Gene Polymorphisms with Cancer Susceptibility and Circulating Levels of IGF-1, IGFBP-2, and IGFBP-3 in Colorectal …

MH Alrashid, AE Al-Serri, RF Hussain, SA Al-Bustan… - Biomedicines, 2023 - mdpi.com
Early detection of colorectal cancer (CRC) increases the 5-year survival rate by 90%;
therefore, non-invasive biomarkers such as measurable circulating proteins for early …

Improving genetic risk modeling of dementia from real-world data in underrepresented populations

M Fu, L Valiente-Banuet, SS Wadhwa… - medRxiv, 2024 - medrxiv.org
BACKGROUND: Genetic risk modeling for dementia offers significant benefits, but studies
based on real-world data, particularly for underrepresented populations, are limited …

Improving genetic risk modeling of dementia from real-world data in underrepresented populations

T Chang, M Fu, L Valiente-Banuet, S Wadhwa… - 2024 - researchsquare.com
BACKGROUND: Genetic risk modeling for dementia offers significant benefits, but studies
based on real-world data, particularly for underrepresented populations, are limited …