Aristolochic acid I as an emerging biogenic contaminant involved in chronic kidney diseases: A comprehensive review on exposure pathways, environmental health …

AT Lukinich-Gruia, J Nortier, NM Pavlović… - Chemosphere, 2022 - Elsevier
Described in the 1950s, Balkan Endemic Nephropathy (BEN) has been recognized as a
chronic kidney disease (CKD) with clinical peculiarities and multiple etiological factors …

Factors influencing the fate of chemical food safety hazards in the terrestrial circular primary food production system—A comprehensive review

W Huang, M Focker, KCW van Dongen… - … Reviews in Food …, 2024 - Wiley Online Library
Food safety is recognized as a major hurdle in the transition toward circular food production
systems due to the potential reintroduction and accumulation of chemical contaminants in …

Occurrence and stability of PCMX in water environments and its removal by municipal wastewater treatment processes

CK Au, KKJ Chan, W Chan, X Zhang - Journal of Hazardous Materials, 2023 - Elsevier
Abstract Para-chloro-meta-xylenol (PCMX) is a synthetic antiseptic used extensively to
control the spread of germs and viruses, and as a result, enormous amount of PCMX could …

Fabrication of a Simple and Efficient HPLC Reduction Column for Online Conversion of Aristolochic Acids to Aristolactams Prior to Sensitive Fluorescence Detection

ML Chin, CK Au, CK Chan, L Jin… - Analytical …, 2023 - ACS Publications
Aristolochic acids (AAs) are nephrotoxic and carcinogenic nitrophenanthrene carboxylic
acids produced naturally by plants from the Aristolochia and Asarum genera, which have …

Broad-specificity indirect competitive enzyme-linked immunosorbent assay for aristolochic acids: Computer-aided hapten design and molecular mechanism of …

X Wang, Q Lu, L Dou, M Liu, P Li, W Yu, X Yu… - Science of The Total …, 2023 - Elsevier
Long-term dietary exposure of aristolochic acids (AAs)-contaminated food proved to be one
of the main culprits of Endemic Nephropathy, renal failure; and urothelial cancer. The …

Synergistic interaction of polycyclic aromatic hydrocarbons, phthalate esters, or phenol on DNA adduct formation by aristolochic acid I: Insights into the etiology of …

J Zhang, KKJ Chan, W Chan - Chemical Research in Toxicology, 2022 - ACS Publications
Balkan endemic nephropathy (BEN) is a multifactorial environmental disease, with chronic
exposure to aristolochic acids (AAs) through AA-contaminated food being one of the major …

Involvement of REV-ERBα dysregulation and ferroptosis in aristolochic acid I-induced renal injury

Y Wang, Z Wang, Z Wu, M Chen, D Dong, P Yu… - Biochemical …, 2021 - Elsevier
The molecular events underlying aristolochic acid (AA) nephropathy are poorly understood,
and specific therapies for treatment of AA nephropathy are still lacking. Here we aimed to …

Analysis of polycyclic aromatic hydrocarbons and phthalate esters in soil and food grains from the Balkan Peninsula: implication on DNA adduct formation by …

W Guo, J Zhang, Z Sun, WH Orem… - Environmental …, 2021 - ACS Publications
Balkan endemic nephropathy (BEN) is a chronic tubulointerstitial nephropathy affecting
residents of rural farming areas in many Balkan countries. Although it is generally believed …

Effects of diet on aristolochic acid-DNA adduct formation: Implications for Balkan endemic nephropathy etiology

J Zhang, CK Chan, NM Pavlovic… - Chemical research in …, 2023 - ACS Publications
Prolonged exposure to aristolochic acids (AAs) through AA-containing herbal medicine or
AA-contaminated food is associated with the development of aristolochic acid nephropathy …

Aristolochic Acids and Aristoloxazines Are Widespread in the Soil of Aristolochiaceae Herb Cultivation Fields

ML Chin, H Zhang, CK Au, WL Luk, Z Cai… - … Science & Technology, 2024 - ACS Publications
The cancer risk associated with aristolochic acid (AA) exposure through the consumption of
AA-containing herbal medicine has received tremendous attention in the past decades …