Oxytocin for the treatment of drug and alcohol use disorders

MR Lee, EM Weerts - Behavioural pharmacology, 2016 - journals.lww.com
There is growing interest in the use of oxytocin (OT) as a potential treatment for alcohol and
other substance-use disorders. OT is a neuropeptide that modulates adaptive processes …

Rebalancing the addicted brain: oxytocin interference with the neural substrates of addiction

MT Bowen, ID Neumann - Trends in neurosciences, 2017 - cell.com
Drugs that act on the brain oxytocin (OXT) system may provide a much-needed treatment
breakthrough for substance-use disorders. Targeting the brain OXT system has the potential …

The role of oxytocin in alcohol and drug abuse

CE King, A Gano, HC Becker - Brain research, 2020 - Elsevier
The neuropeptide oxytocin (OXT) plays a key role in adaptive processes associated with
reward, tolerance, memory and stress responses. Through interactions with brain reward …

Targeting the oxytocin system to treat addictive disorders: rationale and progress to date

MR Lee, MCH Rohn, G Tanda, L Leggio - CNS drugs, 2016 - Springer
The neuropeptide oxytocin plays a role in reward, stress, social affiliation, learning, and
memory processes. As such, there is increasing interest in oxytocin as a potential treatment …

Effect of early life social adversity on drug abuse vulnerability: Focus on corticotropin-releasing factor and oxytocin

MT Bardo, LR Hammerslag, SG Malone - Neuropharmacology, 2021 - Elsevier
Early life adversity can set the trajectory for later psychiatric disorders, including substance
use disorders. There are a host of neurobiological factors that may play a role in the …

The effects of intranasal oxytocin on reward circuitry responses in children with autism spectrum disorder

RK Greene, M Spanos, C Alderman, E Walsh… - Journal of …, 2018 - Springer
Background Intranasal oxytocin (OT) has been shown to improve social communication
functioning of individuals with autism spectrum disorder (ASD) and, thus, has received …

Oxytocin signaling in the treatment of drug addiction: Therapeutic opportunities and challenges

X Che, J Cai, Y Liu, T Xu, J Yang, C Wu - Pharmacology & therapeutics, 2021 - Elsevier
Drug addiction is one of the leading causes of mortality worldwide. Despite great advances
were achieved in understanding the neurobiology of drug addiction, the therapeutic options …

Environmental enrichment enhances conditioned place preference to ethanol via an oxytocinergic-dependent mechanism in male mice

M Rae, P Zanos, P Georgiou, P Chivers, A Bailey… - …, 2018 - Elsevier
Environmental conditions, such as stress and environmental enrichment (EE), influence
predisposition to alcohol use/abuse; however, the underlying mechanisms remain unknown …

Oxytocin and opioid addiction revisited: old drug, new applications

P Zanos, P Georgiou, C Weber… - British journal of …, 2018 - Wiley Online Library
Opioid addiction has devastating health and socio‐economic consequences, and current
pharmacotherapy is limited and often accompanied by side effects, thus novel treatment is …

Magnocellular neurons and posterior pituitary function

CH Brown - Comprehensive physiology, 2011 - Wiley Online Library
The posterior pituitary gland secretes oxytocin and vasopressin (the antidiuretic hormone)
into the blood system. Oxytocin is required for normal delivery of the young and for delivery …