Hepatitis C virus (HCV) infection and its complications have been the major cause of
cirrhosis and its complications for several decades in the Western world. Until recently …

Liver fibrosis is the excessive accumulation of extracellular matrix proteins including
collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in …

Angiotensin II (Ang II) is a pro-oxidant and fibrogenic cytokine. We investigated the role of
NADPH oxidase in Ang II–induced effects in hepatic stellate cells (HSCs), a fibrogenic cell …

Background: Angiotensin converting enzyme (ACE) 2 is a recently identified homologue of
ACE that may counterregulate the actions of angiotensin (Ang) II by facilitating its breakdown …

Chronic liver injury of different etiologies may result in hepatic fibrosis, a scar formation
process consisting in altered deposition of extracellular matrix. Progression of fibrosis can …

Background/Aims: Obesity is associated with hyperleptinemia and is also a risk factor for
fibrosis and severity of fibrosis in several chronic liver diseases. The correlation between …

Significance: Hepatic fibrosis is the common pathophysiologic process resulting from
chronic liver injury, characterized by the accumulation of an excessive extracellular matrix …

BACKGROUND & AIMS:: The renin-angiotensin system plays an important role in hepatic
fibrogenesis. In other organs, myofibroblasts accumulated in damaged tissues generate …

Portal hypertension and bleeding from gastroesophageal varices is the major cause of
morbidity and mortality in patients with cirrhosis. Portal hypertension is initiated by increased …

The renin-angiotensin system (RAS) conceived as a coordinated hormonal cascade plays
an important role in controlling multiple functions in many organs and is much more complex …