Histone deacetylases (HDACs), a class of enzymes responsible for the removal of acetyl
functional groups from the lysine residues in the amino-terminal tails of core histones, play a …

The rising prevalence of drug-resistant pathogens is one of the biggest threats to human
health. The development of new antibiotics that can overcome drug resistance is in urgent …

Two new series of thiazole and formazan linked to 5-Bromo-indan were synthesized, and
their structures were assured based on all possible analytical techniques. The size of the …

The rapid construction of three‐dimensional (3D) heterocyclic frameworks is a key challenge
in contemporary medicinal chemistry. The molecules with three‐dimensional complexity …

Abstract Current treatment for Glioblastoma Multiforme (GBM) is not efficient due to its
aggressive nature, tendency to infiltrate surrounding brain tissue, and chemotherapy …

Faced with the growing demands for natural products, the marine environment is a potential
source for the discovery of therapeutic compounds. The aim of this study was to evaluate the …

Tea, a worldwide popular beverage rich in polyphenols, contributes to the prevention of
many diseases and thus is beneficial to human health. Tea is a product through processing …

In this study, we synthesized new 5, 6, 7, 8-tetrahydroisoquinolines and 6, 7, 8, 9-
tetrahydrothieno [2, 3-c] isoquinolines based on 4-(N, N-dimethylamino) phenyl moiety as …

Background The liver serves as a metabolic hub within the human body, playing a crucial
role in various essential functions, such as detoxification, nutrient metabolism, and hormone …

Herein, we describe a chemo-and diastereoselective formal C–C insertion reaction of 1, 2-
disubstituted 4-diazo-3 (2 H)-isoquinolones and 4-diazoisochroman-3-one into C–CHO …