A long-lasting porcine model of ARDS caused by pneumonia and ventilator-induced lung injury

E Barbeta, M Arrieta, A Motos, J Bobi, H Yang, M Yang… - Critical Care, 2023 - Springer
Background Animal models of acute respiratory distress syndrome (ARDS) do not
completely resemble human ARDS, struggling translational research. We aimed to …

Oxygen therapy alternatives in COVID-19: From classical to nanomedicine

LFT Pereira, CA Dallagnol, TH Moulepes, CY Hirota… - Heliyon, 2023 - cell.com
Abstract Around 10–15% of COVID-19 patients affected by the Delta and the Omicron
variants exhibit acute respiratory insufficiency and require intensive care unit admission to …

Systemically injected oxygen within rapidly dissolving microbubbles improves the outcomes of severe hypoxaemia in swine

JG Mancebo, K Sack, J Hartford… - Nature Biomedical …, 2024 - nature.com
Acute respiratory failure can cause profound hypoxaemia that leads to organ injury or death
within minutes. When conventional interventions are ineffective, the intravenous …

[HTML][HTML] Peritoneal Infusion of Oxygen Microbubbles Alters the Metabolomic Profile of the Lung and Spleen in Acute Hypoxic Exposure

C Lisk, A Fan, FI Cendali, K Kakiuchi, D Swindle… - Bioengineering, 2024 - mdpi.com
Administration of oxygen microbubbles (OMBs) has been shown to increase oxygen and
decrease carbon dioxide in systemic circulation, as well as reduce lung inflammation and …

Effect of Lipid Composition and Stirring Dynamics on Oxygen Microbubble Stability and Oxygen Release

K Kakiuchi, MA Borden - Langmuir, 2025 - ACS Publications
Lipid-coated oxygen microbubbles (OMBs) are being investigated for biomedical
applications to alleviate hypoxia such as systemic oxygenation and image-guided …

Intraluminal oxygen mitigates acute mesenteric ischaemia: a systematic review of methods and outcomes in animal studies

D Joh, M Morreau, A Lee, S Pendharkar… - ANZ Journal of …, 2023 - Wiley Online Library
Abstract Background Acute Mesenteric Ischaemic (AMI) is a rare condition with significant
morbidity and mortality. Many causes of AMI exist, which usually begin with mucosal injury …

Dynamics and metabolic effects of intestinal gases in healthy humans

A Tozzi, R Minella - Biochimie, 2024 - Elsevier
Many living beings use exogenous and/or endogenous gases to attain evolutionary benefits.
We make a comprehensive assessment of one of the major gaseous reservoirs in the …

[HTML][HTML] Enteral liquid ventilation oxygenates a hypoxic pig model

T Fujii, Y Yoneyama, A Kinebuchi, N Ozeki, S Maeda… - Iscience, 2023 - cell.com
The potential of extrapulmonary ventilation pathways remains largely unexplored. Here, we
assessed the enteral ventilation approach in hypoxic porcine models under controlled …

[PDF][PDF] A long-lasting porcine model of ARDS caused by pneumonia and ventilator-induced lung injury

G Tanzella, P Di Ginnatale, S Nogas, CR Vargas… - 2023 - ccforum.biomedcentral.com
Background Animal models of acute respiratory distress syndrome (ARDS) do not
completely resemble human ARDS, struggling translational research. We aimed to …

Biological Relevance of Intestinal Gases in Healthy Humans

A Tozzi, R Minella - 2022 - preprints.org
Intestinal gases are usually discarded as physiologically inert, useless sub-products of
colonic fermentation that must be expelled to prevent discomfort and meteorism. Starting …