[HTML][HTML] IUPHAR review–Data-driven computational drug repurposing approaches for opioid use disorder
Abstract Opioid Use Disorder (OUD) is a chronic and relapsing condition characterized by
the misuse of opioid drugs, causing significant morbidity and mortality in the United States …
the misuse of opioid drugs, causing significant morbidity and mortality in the United States …
Emerging therapies for opioid-induced constipation: what can we expect?
G Roostaei, N Khoshnam Rad… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction The rise in opioid use for managing chronic and oncologic pain has led to a
significant increase in opioid-induced constipation (OIC) that impacts patient quality of life …
significant increase in opioid-induced constipation (OIC) that impacts patient quality of life …
Peripherally‐active mu‐opioid receptor antagonists for constipation in critically ill patients receiving opioids: A case‐series and a systematic review and meta‐analysis …
M Umbrello, R Venco, C Palandri… - …, 2023 - Wiley Online Library
Background Constipation is frequent in critically ill patients, and potentially related to
adverse outcomes. Peripherally‐active mu‐opioid receptor antagonists (PAMORAs) are …
adverse outcomes. Peripherally‐active mu‐opioid receptor antagonists (PAMORAs) are …
An update on the use of pharmacotherapy for opioid-induced bowel dysfunction
Introduction With the growing rate of aging and the incidence of chronic diseases, there has
been an upsurge in opioid prescription and abuse worldwide. This has been associated with …
been an upsurge in opioid prescription and abuse worldwide. This has been associated with …
Targeting human thymidylate synthase: Ensemble-based virtual screening for drug repositioning and the role of water
A drug repositioning computational approach was carried to search inhibitors for human
thymidylate synthase. An ensemble-based virtual screening of FDA-approved drugs showed …
thymidylate synthase. An ensemble-based virtual screening of FDA-approved drugs showed …
Safety of Naldemedine for Opioid-Induced Constipation–A Systematic Review and Meta-Analysis
B Wobbe, M Gerner, CH Köhne - Journal of Pain & Palliative Care …, 2024 - Taylor & Francis
Naldemedine is a peripheral acting µ-opioid receptor antagonist approved by the Food and
Drug Administration to treat opioid-induced constipation. Concerns about side effects like …
Drug Administration to treat opioid-induced constipation. Concerns about side effects like …