The roles of circRNA–miRNA–mRNA networks in the development and treatment of osteoporosis

M Gao, Z Zhang, J Sun, B Li, Y Li - Frontiers in endocrinology, 2022 - frontiersin.org
Osteoporosis is a systemic metabolic disease, mainly characterized by reduced bone
mineral density and destruction of bone tissue microstructure. However, the molecular …

CircRNA-mediated ceRNA mechanism in Osteoarthritis: Special emphasis on circRNAs in exosomes and the crosstalk of circRNAs and RNA methylation

Q Xue, Y Huang, J Chang, C Cheng, Y Wang… - Biochemical …, 2023 - Elsevier
Osteoarthritis (OA) is an age-related joint disease with chronic inflammation, progressive
articular cartilage destruction and subchondral bone sclerosis. CircRNAs (circRNAs) are a …

Circ_0114581 promotes osteogenic differentiation of BMSCs via the MiR-155-5p/HNRNPA3 axis

H Li, C Wang, J Yao, Y Jin, X Song, Q Meng, J Wu… - Life Sciences, 2023 - Elsevier
Osteoporosis (OP) is a common metabolic bone disease characterized by deterioration of
bone tissue structure, reduction of bone mass, and susceptibility to fracture. More and new …

Circular RNAs: promising targets in osteoporosis

SR Moura, MJ Fernandes, SG Santos… - Current Osteoporosis …, 2023 - Springer
Abstract Purpose of Review Circular RNAs (circRNAs) are RNA transcripts derived from
fragments of pre-messenger RNAs through a back-splicing process. An advantage that rises …

Post-transcriptional regulatory crosstalk between MicroRNAs and canonical TGF-β/BMP signalling cascades on osteoblast lineage: a comprehensive review

HY Loh, BP Norman, KS Lai, WH Cheng… - International Journal of …, 2023 - mdpi.com
MicroRNAs (miRNAs) are a family of small, single-stranded, and non-protein coding RNAs
about 19 to 22 nucleotides in length, that have been reported to have important roles in the …

The potential effect of BMSCs with miR‐27a in improving steroid-induced osteonecrosis of the femoral head

Y Cui, T Huang, Z Zhang, Z Yang, F Hao, T Yuan… - Scientific Reports, 2022 - nature.com
Steroid induced osteonecrosis of the femoral head (ONFH) frequently leads to femoral head
collapse and subsequent hip arthritis. This study aimed to investigate the potential …

CircGNB1 drives osteoarthritis pathogenesis by inducing oxidative stress in chondrocytes

Y Liang, L Shen, W Ni, Y Ding, W Yang… - Clinical and …, 2023 - Wiley Online Library
Abstract Background Circular RNAs (circRNAs) have risen to prominence as important
regulators of biological processes. This study investigated whether circGNB1 functions as a …

Regulation of TGF-β/BMP signaling during osteoblast development by non-coding RNAs: Potential therapeutic applications

I Saranya, N Selvamurugan - Life Sciences, 2024 - Elsevier
Bone is a connective tissue that is metabolically active and serves multiple functions,
including movement, structural support, and organ protection. It is comprised primarily of …

Ursolic acid alleviates steroid-induced avascular necrosis of the femoral head in mouse by inhibiting apoptosis and rescuing osteogenic differentiation

Q Liu, Y Wu, S Li, S Yoon, J Zhang, X Wang… - Toxicology and Applied …, 2023 - Elsevier
Steroid-induced avascular necrosis of femoral head (SANFH) is a common disorder
worldwide with high disability. Overdose of glucocorticoid (GC) is the most common non …

Insight into Steroid-Induced ONFH: The Molecular Mechanism and Function of Epigenetic Modification in Mesenchymal Stem Cells

C Huang, L Qing, Y Xiao, J Tang, P Wu - Biomolecules, 2023 - mdpi.com
Osteonecrosis of the femoral head (ONFH) is a common refractory orthopedic disease,
which is one of the common causes of hip pain and dysfunction. ONFH has a very high …