Target-based high-throughput screening (HTS) has recently been critiqued for its relatively
poor yield compared to phenotypic screening approaches. One type of phenotypic …

The last decade has seen the development of automated microscopy and its adaptation for
various areas of research, particularly infectious disease. Most of the high-content screening …

Glioma cells with stem cell traits are thought to be responsible for tumor maintenance and
therapeutic failure. Such cells can be enriched based on their inherent drug efflux capability …

Morphological profiling is an omics-based approach for predicting intracellular targets of
chemical compounds in which the dose-dependent morphological changes induced by the …

Access to high quality photoaffinity probe molecules is often constrained by synthetic
limitations related to diazirine installation. A survey of recently published photoaffinity probe …

Traditional drug discovery efforts have resulted in the approval of a handful of receptor
tyrosine kinase (RTK) inhibitors; however, their discovery relied solely on screening …

A novel single step assay approach to screen a library of photdynamic therapy (PDT)
compounds was developed. Utilizing high content analysis (HCA) technologies several …

Lipid-based nanoparticles (LNPs) are widely used for the delivery of drugs and nucleic
acids. Although most of them are considered safe, there is confusing evidence in the …

RNA interference technology is becoming an integral tool for target discovery and
validation.; With perhaps the exception of only few studies published using arrayed short …

Doxorubicin (DOX) is an effective chemotherapy drug for various types of cancer. However,
acute and chronic cardiotoxicity of DOX hamper its clinical application. There is a great …