Obesity has been well recognized as an important comorbidity in patients with asthma,
representing a unique phenotype and endotype. This association indicates a close …

The prevalence rates of obesity and its complications have increased dramatically
worldwide. Obesity can lead to low-grade chronic systemic inflammation, which predisposes …

Corticosteroid insensitivity in asthma limits the ability to effectively manage severe asthma,
which is characterized by persistent airway inflammation, airway hyperresponsiveness …

The prevalence of obesity in children has dramatically increased in the last few decades,
and obesity has also emerged as an important risk factor for asthma. Innate mechanisms …

OBJECTIVE: To explore the mechanism of TLR7 mediating NF-κB signaling pathway on the
pathogenesis of bronchial asthma in mice and the intervention effect of IFN-γ in the process …

Obesity is a risk factor for the development of asthma and represents a difficult-to-treat
disease phenotype. Aerobic glycolysis is emerging as a key feature of asthma, and changes …

Bronchial asthma (BA) is a heterogeneous disease. Some patients benefit greatly from
glucocorticoid (GC) treatment, whereas others are non-responders. This could be …

Introduction: Airway hyperresponsiveness (AHR) is a cardinal feature of asthma. Asthma is a
heterogenous disorder which consists of different phenotypes and endotypes. Mechanisms …

激素抵抗型哮喘治疗困难, 一直是哮喘研究的重点和难点. 研究发现糖皮质激素受体(
glucocorticoid receptor, GR) 异常, 组蛋白去乙酰化酶2 (histone deacetylase, HDAC2) …

The 'era of corticosteroids' brought about a revolutionary change in the course of asthma
treatment in the mid-twentieth century. A few decades later, a lack of response to …