The transforming growth factor β (TGF-β) family of growth factors control the development
and homeostasis of most tissues in metazoan organisms. Work over the past few years has …

The transforming growth factor ß (TGF-ß) family of hormonally active polypeptides have
attracted much attention because of their ability to control cellular functions that underwrite …

We investigated the molecular basis for osteolytic bone metastasis by selecting human
breast cancer cell line subpopulations with elevated metastatic activity and functionally …

▪ Abstract Myostatin is a secreted protein that acts as a negative regulator of skeletal muscle
mass. During embryogenesis, myostatin is expressed by cells in the myotome and in …

BACKGROUND Endometriosis is estimated to affect 1 in 10 women during the reproductive
years. There is often delay in making the diagnosis, mainly due to the non-specific nature of …

It is widely accepted that the growth and regeneration of tissues and organs is tightly
controlled. Although experimental studies are beginning to reveal molecular mechanisms …

TGF-β ligands stimulate diverse cellular differentiation and growth responses by signaling
through type I and II receptors. Ligand antagonists, such as follistatin, block signaling and …

It has been 70 years since the name inhibin was used to describe a gonadal factor that
negatively regulated pituitary hormone secretion. The majority of this period was required to …

Myostatin, a member of the TGFβ superfamily, is a potent and specific negative regulator of
skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing …

Follistatin was first described in 1987 as a follicle-stimulating hormone inhibiting substance
present in ovarian follicular fluid. We now know that this effect of follistatin is only one of its …