ABSTRACT rRNAs are extensively modified during their transcription and subsequent
maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed …

Ribosomal RNAs are the most abundant and universal noncoding RNAs in living organisms.
In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S subunits are borne …

Ribosomes play a pivotal role in the molecular life of every cell. Moreover, synthesis of
ribosomes is one of the most energetically demanding of all cellular processes. In eukaryotic …

Mammalian RNA complexity is regulated through interactions of RNA-binding proteins
(RBPs) with their target transcripts. High-throughput sequencing together with UV …

The identification of sites where RNA-binding proteins (RNABPs) interact with target RNAs
opens the door to understanding the vast complexity of RNA regulation. UV cross-linking …

Alternative splicing is a highly regulated process that greatly increases the proteome
diversity and plays an important role in cellular differentiation and disease. Interactions …

The RNA binding proteome (RBP ome) was previously investigated using UV crosslinking
and purification of poly (A)‐associated proteins. However, most cellular transcripts are not …

Eukaryotic small ribosomal subunits are first assembled into 90S pre-ribosomes. The
complete 90S is a gigantic complex with a molecular mass of approximately five …

Ribosome assembly in eukaryotes requires approximately 200 essential assembly factors
(AFs) and occurs through ordered events that initiate in the nucleolus and culminate in the …

The exosome plays major roles in RNA processing and surveillance but the in vivo target
range and substrate acquisition mechanisms remain unclear. Here we apply in vivo RNA …