N-Methyl-D-aspartate ionotropic glutamate receptors (NMDARs) play key roles in
synaptogenesis, synaptic maturation, long-term plasticity, neuronal network activity, and …

Synapse organizing proteins are multifaceted molecules that coordinate the complex
processes of brain development and plasticity at the level of individual synapses. Their …

Proteins critical for synaptic transmission are non-uniformly distributed and assembled into
regions of high density called subsynaptic densities (SSDs) that transsynaptically align in …

The fluorescent glutamate indicator iGluSnFR enables imaging of neurotransmission with
genetic and molecular specificity. However, existing iGluSnFR variants exhibit low in vivo …

Action potentials trigger neurotransmitter release at the presynaptic active zone with
spatiotemporal precision. This is supported by protein machinery that mediates synaptic …

The architecture of the actin cytoskeleton that concentrates at presynapses remains poorly
known, hindering our understanding of its roles in synaptic physiology. In this work, we …

AMPA glutamate receptors (AMPARs), the primary mediators of excitatory
neurotransmission in the brain, are either GluA2 subunit-containing and thus Ca2+ …

Synaptic adhesion molecules (SAMs) shape the structural and functional properties of
synapses and thereby control the information processing power of neural circuits. SAMs are …

A key feature of excitatory synapses is the existence of subsynaptic protein nanoclusters
(NCs) whose precise alignment across the cleft in a transsynaptic nanocolumn influences …

Heterotetrameric glutamate receptors are essential for the development, function, and
plasticity of spine synapses but how they are organized to achieve this is not known. Here …