Metal ions provide considerable functionality across biological systems, and their utilization
within biomolecules has adapted through changes in the chemical environment to maintain …

Wilson disease (WD) is caused by autosomal variants affecting the ATP7B gene on
chromosome 13, resulting in alterations in physiological copper homeostasis and copper …

Wilson disease is a genetic disorder of the liver characterized by excess accumulation of
copper, which is found ubiquitously on earth and normally enters the human body in small …

The importance of metal biology in neurodegenerative diseases such as Huntingtin Disease
is well documented with evidence of direct interactions between metals such as copper …

Simple Summary Cuproptosis is a recently identified form of cell death induced by
imbalanced copper levels. We aimed to explore the mechanism underlying copper-induced …

Background: Wilson's disease (WD) is a rare inherited genetic disorder characterized by the
progressive accumulation of copper in the brain, liver, and other major organ systems. To …

Metals—especially iron, copper and manganese—are important elements of brain functions
and development. Metal-dysregulation homeostasis is associated with brain-structure …

Humans are continuously exposed to various heavy metals including copper, iron, cadmium,
and arsenic, which were specifically selected for the current analysis because they are …

Aim To discover the novel ATP7B mutations in 103 southern Chinese patients with Wilson
disease (WD), and to determine the spectrum and frequency of mutations in the ATP7B gene …

Diseases of the skin, hair, nails and mucosa can appear as flesh-colored lesions or may
present as any of the colors of the visual spectrum. Diseases associated with blue (or …