Sarcopenia: aging-related loss of muscle mass and function

L Larsson, H Degens, M Li, L Salviati… - Physiological …, 2019 - journals.physiology.org
Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

Healthy aging and the blood–brain barrier

WA Banks, MJ Reed, AF Logsdon, EM Rhea… - Nature aging, 2021 - nature.com
The blood–brain barrier (BBB) protects the central nervous system (CNS) from unregulated
exposure to the blood and its contents. The BBB also controls the blood-to-brain and brain …

Fighting against skin aging: the way from bench to bedside

S Zhang, E Duan - Cell transplantation, 2018 - journals.sagepub.com
As the most voluminous organ of the body that is exposed to the outer environment, the skin
suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features …

Deciphering the endometrial niche of human thin endometrium at single-cell resolution

H Lv, G Zhao, P Jiang, H Wang… - Proceedings of the …, 2022 - National Acad Sciences
Thin endometrium has been widely recognized as a critical cause of infertility, recurrent
pregnancy loss, and placental abnormalities; however, access to effective treatment is a …

Ageing, metabolism and cardiovascular disease

S Costantino, F Paneni… - The Journal of physiology, 2016 - Wiley Online Library
Age is one of the major risk factors associated with cardiovascular disease (CVD). About
one‐fifth of the world population will be aged 65 or older by 2030, with an exponential …

The neuropathology and cerebrovascular mechanisms of dementia

L Raz, J Knoefel, K Bhaskar - Journal of Cerebral Blood Flow …, 2016 - journals.sagepub.com
The prevalence of dementia is increasing in our aging population at an alarming rate.
Because of the heterogeneity of clinical presentation and complexity of disease …

[HTML][HTML] Age-related impairment of vascular structure and functions

X Xu, B Wang, C Ren, J Hu, DA Greenberg… - Aging and …, 2017 - ncbi.nlm.nih.gov
Among age-related diseases, cardiovascular and cerebrovascular diseases are major
causes of death. Vascular dysfunction is a key characteristic of these diseases wherein age …

Pathological changes within the cerebral vasculature in Alzheimer's disease: New perspectives

RA Fisher, JS Miners, S Love - Brain Pathology, 2022 - Wiley Online Library
Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis

N Caporarello, J Lee, TX Pham, DL Jones… - Nature …, 2022 - nature.com
Vascular dysfunction is a hallmark of chronic diseases in elderly. The contribution of the
vasculature to lung repair and fibrosis is not fully understood. Here, we performed an …

Age‐related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review

B Zimmerman, B Rypma, G Gratton… - …, 2021 - Wiley Online Library
The process of aging includes changes in cellular biology that affect local interactions
between cells and their environments and eventually propagate to systemic levels. In the …