ABSTRACT CYLD lysine 63 deubiquitinase (CYLD) is a ubiquitin hydrolase with important
roles in immunity and cancer. Complete CYLD ablation, truncation and expression of …

Aims Tumours of the cutaneous adnexa arise from, or differentiate towards, structures in
normal skin such as hair follicles, sweat ducts/glands, sebaceous glands or a combination of …

Background MBD4 mutations have been reported in uveal melanomas, acute myeloid
leukemias, colorectal adenocarcinomas, gliomas, and spiradenocarcinomas and cause a …

Aim & methods: We conducted a pilot epigenome-wide association study of women from
Tutsi ethnicity exposed to the genocide while pregnant and their resulting offspring, and a …

CYLD cutaneous syndrome (CCS) typically manifests in the second or third decade with the
appearance of multiple skin tumors including cylindromas, spiradenomas …

Wound healing in the skin is a complex physiological process that is a product of a cell state
transition from homeostasis to repair. Mechanical cues are increasingly being recognized as …

Simple Summary Retinoblastoma, a childhood cancer of the eye, is thought to be caused by
inactivating mutations of both copies of the RB1 gene. The majority of RB1 mutations can be …

The clinical presentation of skin appendage tumours for the most part is not as specific and
diverse as the histological features of this extremely heterogeneous tumour group …

The problem with cancer tissue is that its intratumoral heterogeneity and its complexity is
extremely high as cells possess, depending on their location and function, different …

Continuous exposure of the skin to environmental, mechanical and chemical stress
necessitates constant self‐renewal of the epidermis to maintain its barrier function. This self …