Messenger RNA Therapy for Female Reproductive Health

R VanKeulen-Miller, OS Fenton - Molecular Pharmaceutics, 2024 - ACS Publications
Female reproductive health has traditionally been an underrepresented area of research in
the drug delivery sciences. This disparity is also seen in the emerging field of mRNA …

Lipid Nanoparticle (LNP) Delivery Carrier-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity

L Wu, X Li, X Qian, S Wang, J Liu, J Yan - Vaccines, 2024 - mdpi.com
In recent years, lipid nanoparticles (LNPs) have attracted extensive attention in tumor
immunotherapy. Targeting immune cells in cancer therapy has become a strategy of great …

A trivalent HSV-2 gC2, gD2, gE2 nucleoside-modified mRNA-LNP vaccine provides outstanding Protection in mice against genital and non-genital HSV-1 infection …

KP Egan, S Awasthi, G Tebaldi, LM Hook… - Viruses, 2023 - mdpi.com
HSV-1 disease is a significant public health burden causing orofacial, genital, cornea, and
brain infection. We previously reported that a trivalent HSV-2 gC2, gD2, gE2 nucleoside …

Debulking Influenza and Herpes Simplex virus strains by a wide-spectrum anti-viral protein formulated in clinical grade chewing gum.

H Daniell, Y Guo, R Singh, U Karki, RJ Kulchar… - Molecular Therapy, 2024 - cell.com
ABSTRACT Lack of Herpes Simplex Virus (HSV) vaccine, low vaccination rates of Influenza
viruses, waning immunity and viral transmission after vaccination underscore the need to …

[HTML][HTML] Carrier-free mRNA vaccine induces robust immunity against SARS-CoV-2 in mice and non-human primates without systemic reactogenicity

S Abbasi, M Matsui-Masai, F Yasui, A Hayashi… - Molecular Therapy, 2024 - cell.com
Carrier-free naked mRNA vaccines may reduce the reactogenicity associated with delivery
carriers; however, their effectiveness against infectious diseases has been suboptimal. To …

[HTML][HTML] Toward the Eradication of Herpes Simplex Virus: Vaccination and Beyond

JY Chang, C Balch, HS Oh - Viruses, 2024 - mdpi.com
Herpes simplex virus (HSV) has coevolved with Homo sapiens for over 100,000 years,
maintaining a tenacious presence by establishing lifelong, incurable infections in over half …

[HTML][HTML] Immunological Considerations for the Development of an Effective Herpes Vaccine

M Singer, MI Husseiny - Microorganisms, 2024 - mdpi.com
Research is underway to develop a vaccine to prevent and cure infection from herpes
simplex virus (HSV). It emphasizes the critical need for immunization to address public …

Reducing HSV-2 morbidity and mortality: routine serologic screening still not the best answer

MD Pearlman - JAMA, 2023 - jamanetwork.com
Humans are the only natural host and reservoir of herpes simplex virus (HSV) types 1 (HSV-
1) and 2 (HSV-2), and together HSV is among the most prevalent viral infections in the …

Jet injection potentiates naked mRNA SARS-CoV-2 vaccine in mice and non-human primates by adding physical stress to the skin

S Abbasi, M Matsui-Masai, F Yasui, A Hayashi… - bioRxiv, 2023 - biorxiv.org
Naked mRNA-based vaccines may reduce the reactogenicity associated with delivery
carriers, but their effectiveness has been suboptimal against infectious diseases. Herein, we …

单纯疱疹病毒2 型ICP27377-513 核酸疫苗联合IL-15 核酸疫苗免疫效果的观察.

韩小艳, 吴振村, 周艳, 贾凤珍… - Guangdong Medical …, 2024 - search.ebscohost.com
目的构建表达HIde 病f 2 ç! 细胞OP 27 (infectedcellsprotein27, ICP27) 的Ý 组g pcDNA3.
1rICP27377r513 并34P 细胞2 素(IL) r15Óh 疫Ñ 联ä HSVr2rICP27377r513Óh 疫Ñ …